Related Party Transaction - Additional information (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021	Dec. 31, 2020
Related Party Transaction [Line Items]
Revenue	$ 2,900		$ 8,500
Deferred revenue	80,496	$ 119,782	80,496	$ 119,782	$ 127,235	$ 73,931
Deferred revenue current	54,818		54,818		63,759
Deferred revenue non-current	25,678		25,678		63,476
Investment	36,989		36,989		$ 29,558
Collaboration revenue	13,266	7,204	38,548	20,199
AvenCell Co Co Agreement [Member]
Related Party Transaction [Line Items]
Deferred revenue current	28,500		$ 28,500
Avencelllca
Related Party Transaction [Line Items]
Revenue	$ 5,700	$ 125,000		$ 62,500
Avencelllca | Joint Venture AvenCell [Member]
Related Party Transaction [Line Items]
Equity method investment, ownership percentage	33.33%		33.33%
Avencelllca | AvenCell Co Co Agreement [Member]
Related Party Transaction [Line Items]
Deferred revenue	$ 8,500		$ 8,500
Avencellcoco
Related Party Transaction [Line Items]
Revenue			17,100
Contra Revenue	$ 1,300		$ 1,400