Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (247,550)	$ (115,011)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	3,591	3,225
Equity-based compensation	41,559	17,038
Amortization of investment premiums	4,428	2,868
Loss from equity method investment	5,997	0
Deferral of equity method investment intra-entity profit on sales	5,656	0
Change in fair value of contingent consideration	249	0
In-process research and development charge	55,990	0
Changes in operating assets and liabilities:
Accounts receivable	(824)	137
Prepaid expenses and other current assets	434	(8,703)
Operating lease right-of-use assets	5,368	4,018
Other assets	(802)	(229)
Accounts payable	(3,710)	(2,606)
Accrued expenses	(721)	10,135
Deferred revenue	(30,099)	(11,179)
Operating lease liabilities	(4,458)	(5,050)
Net cash used in operating activities	(164,892)	(105,357)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property and equipment	(5,409)	(5,350)
Purchases of marketable securities	(31,524)	(185,431)
Maturities of marketable securities	224,583	198,499
Acquired in-process research and development, net of cash acquired of $287	(44,832)	0
Net cash provided by investing activities	142,818	7,718
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of common stock through at-the-market offerings, net of issuance costs	38,885	45,255
Proceeds from options exercised	13,262	19,503
Issuance of shares through employee stock purchase plan	1,068	970
Net cash provided by financing activities	53,215	65,728
Net increase (decrease) in cash and cash equivalents and restricted cash equivalents	31,141	(31,911)
Cash and cash equivalents and restricted cash equivalents, beginning of period	125,486	164,606
Cash and cash equivalents and restricted cash equivalents, end of period	156,627	132,695
Reconciliation of cash and cash equivalents and restricted cash equivalents to condensed consolidated balance sheet:
Cash and cash equivalents	147,781	129,879
Restricted cash equivalents, included in investments and other assets	8,846	2,816
Total cash and cash equivalents and restricted cash equivalents	156,627	132,695
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION:
Purchases of property and equipment unpaid at period end	3,750	1,969
Right-of-use assets acquired under operating leases	0	41,974
Contingent consideration liability assumed in asset acquisition	10,541	0
Offering costs unpaid at period end	$ 0	$ 208