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Equity-Based Compensation - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Jan. 31, 2020
May 31, 2016
May 30, 2016
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number       453,026 193,936  
Weighted Average Grant Date Fair Value per Share, Granted       $ 73.81 $ 21.70 $ 0
Number of shares, cancelled       72,467    
Total fair value amount, Vested       $ 14,100,000 $ 2,800,000 $ 600
Number of shares vested       119,715    
Unrecognized equity-based compensation expense related to restricted stock       $ 27,100,000    
Number of Shares, Granted       451,272    
Acceleration resulted in additional expense       $ 47,009,000 $ 19,903,000 $ 15,091,000
Weighted average grant date fair value per share       $ 54.09 $ 9.07 $ 9.21
Total intrinsic value of stock options exercised       $ 262,000,000.0 $ 20,300,000 $ 2,300,000
Unrecognized compensation cost related to stock options       $ 130,300,000    
Stock options outstanding       6,305,156 6,977,440  
Potential dilutive securities excluded from computation of diluted net loss per common share       6,758,000 7,171,000 5,438,000
Performance-based options forfeited       700,700    
Common stock, shares issued       74,485,883 66,234,056  
Restricted Stock [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Weighted average period of unrecognized compensation costs       2 years 9 months 18 days    
RSUs [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Remaining vesting period 3 years          
Weighted Average Grant Date Fair Value per Share, Granted $ 15.05          
Number of Shares, Granted 181,020          
RSUs vested number         58,870  
Stock Options [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Weighted average period of unrecognized compensation costs       3 years 1 month 6 days    
Satisfaction Of a Service Condition            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Number of shares vested       26,235    
Development milestones | RSUs [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Number of shares vested       64,290    
2015 Plan [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Remaining vesting period       3 years    
Description of stock options granted under the Plan       Stock options granted under the 2015 Plan generally vest 25% on the first anniversary of the original vesting date, with the balance vesting monthly over the remaining three years, unless they contain specific performance-based vesting provisions. The maximum term of stock options granted under the 2015 Plan is ten years.    
Shares available for future issuance       2,241,278    
Percentage of cumulative increase in number of shares for future issuance       4.00%    
2015 Plan [Member] | First Anniversary of Original Vesting Date [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Vest percentage on the first anniversary       25.00%    
2016 Employee Stock Purchase Plan [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Description of stock options granted under the Plan     The 2016 Plan allows eligible employees to purchase shares of the Company’s common stock on the last day of each predetermined six-month offering period at 85% of the lower of the fair market value per share at the beginning or end of the applicable offering period.      
Shares available for future issuance       1,297,202    
Weighted Average Grant Date Fair Value per Share, Granted       $ 65.51 $ 15.28 $ 12.05
Common stock, shares issued       30,897 101,911 90,581
Percentage of fair market value of common stock   85.00%        
Maximum [Member] | 2015 Plan [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Maximum term of stock options granted       10 years    
Maximum [Member] | 2016 Employee Stock Purchase Plan [Member]            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]            
Common stock, shares issued       500,000