X0306 4 2022-01-10 0 0001680367 Shattuck Labs, Inc. STTK 0001652066 DeYoung Casi C/O SHATTUCK LABS, INC. 500 W. 5TH STREET, SUITE 1200 AUSTIN TX 78701 0 1 0 0 Chief Business Officer Common Stock 2022-01-10 4 A 0 21363 0.00 A 21363 D Stock Option (Right to Buy) 7.43 2022-01-10 4 A 0 42725 0.00 A 2032-01-10 Common Stock 42725 42725 D Consists of 21,363 restricted stock units, which will vest in four equal annual installments beginning on January 10, 2023, subject to the Reporting Person's continued service to the Issuer. This option represents a right to purchase a total of 42,725 shares of the Issuer's common stock, one quarter of which will vest on January 10, 2023, with the remaining three quarters vesting in equal monthly installments through January 10, 2026, subject to the Reporting Person's continued service to the Issuer. /s/ Erin Ator Thomson, Attorney-in-fact for Casi DeYoung 2022-01-12