X0306 4 2021-06-11 0 0001651944 DermTech, Inc. DMTK 0001739840 Wood Todd Michael C/O DERMTECH, INC. 11099 N. TORREY PINES RD. SUITE 100 LA JOLLA CA 92037 0 1 0 0 Chief Commercial Officer Common Stock 2021-06-11 4 S 0 1398 41.0825 D 151121 D Common Stock 2021-06-11 4 S 0 795 41.3725 D 150326 D Common Stock 2021-06-14 4 S 0 1689 41.2238 D 148637 D Common Stock 2021-06-14 4 S 0 901 41.8365 D 147736 D The shares were sold by the reporting person to generate proceeds used to satisfy the tax withholding obligation that arose upon the vesting of certain restricted stock units granted to the reporting person on June 24, 2020. The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 12,2021. This transaction was executed in multiple trades at prices ranging from $41.30 to $41.42, inclusive. The reported price reflects the weighted average sale price. This transaction was executed in multiple trades at prices ranging from $40.65 to $41.64, inclusive. The reported price reflects the weighted average sale price. This transaction was executed in multiple trades at prices ranging from $41.65 to $41.99, inclusive. The reported price reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3) through (5) of this Form 4. /s/ Jason S. Miller, attorney-in-fact 2021-06-15