X0306 4 2021-05-21 0 0001651944 DermTech, Inc. DMTK 0001787129 Picozza Enrico C/O DERMTECH, INC. 11099 N. TORREY PINES RD. SUITE 100 LA JOLLA CA 92037 1 0 0 0 Common Stock 14000 D Common Stock 2021-05-21 4 S 0 18796 37.2707 D 531204 I By HLM Venture Partners IV, L.P. Common Stock 2021-05-21 4 S 0 6204 37.799 D 525000 I By HLM Venture Partners IV, L.P. Common Stock 2021-05-25 4 S 0 4703 40.0081 D 520297 I By HLM Venture Partners IV, L.P. This transaction was executed in multiple trades at prices ranging from $36.63 to $37.62, inclusive. The reported price reflects the weighted-average sale price. The reporting person has a pecuniary interest in HLM Venture Associates IV, LLC ("HLM GP"). HLM GP is the general partner of HLM Venture Partners IV, L.P., which owns the reported securities. The reporting person disclaims beneficial ownership of the reported securities except to the extent of his pecuniary interest therein. This transaction was executed in multiple trades at prices ranging from $37.63 to $38.15, inclusive. The reported price reflects the weighted-average sale price. This transaction was executed in multiple trades at prices ranging from $40.00 to $40.06, inclusive. The reported price reflects the weighted-average sale price. The reporting person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (1), (3) and (4) of this Form 4. /s/ Jason S. Miller, attorney-in-fact 2021-05-25