X0306 4 2020-09-18 0 0001757898 STERIS plc STE 0001651806 Carestio Daniel A C/O 70 SIR JOHN ROGERSON'S QUAY DUBLIN L2 2 IRELAND 0 1 0 0 Sr VP and Chief Operating Off Ordinary Shares 2020-09-18 4 M 0 15000 69.72 A 41314 D Ordinary Shares 2020-09-18 4 S 0 14794 175.51 D 26520 D Ordinary Shares 2020-09-18 4 S 0 206 176.03 D 26314 D Employee Stock Option (right to buy) 69.72 2020-09-18 4 M 0 15000 0.00 A 2026-06-01 Ordinary Shares 15000 0 D 19,400 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 5,500 on June 1, 2021; 2,712 on May 31, 2022; 1,748 on October 3, 2022; 5,008 on May 31, 2023; 3,324 on June 1, 2023 and 1,108 on June 3, 2024. This exercise of stock options and sale of a total of 14,872 ordinary shares is pursuant to a Rule 10b5-1 Stock Trading Plan entered into by the Reporting Person on February 24, 2020. Price reflects a weighted average sale price for multiple transactions ranging from $175.02 to $176.00 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This exercise of stock options and sale of a total of 128 ordinary shares is pursuant to a Rule 10b5-1 Stock Trading Plan entered into by the Reporting Person on February 24, 2020. Price reflects a weighted average sale price for multiple transactions ranging from $176.02 to $176.03 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. This option to purchase 15,000 STERIS ordinary shares, which is fully vested, was received in conjunction with the Redomiciliation of the entity organized under the laws of the U.K. and formerly named STERIS plc ("Old STERIS"), in exchange for an option to purchase 15,000 Old STERIS ordinary shares for $69.72 per share, subject to the same terms and conditions as the original Old STERIS stock option, except as otherwise required by law. /s/ Ronald E. Snyder, Authorized Representative under Power of Attorney 2020-09-21