X0306 4 2016-12-08 0 0001624899 Steris plc STE 0001651806 Carestio Daniel A C/O CHANCERY HOUSE, 190 WATERSIDE ROAD HAMILTON INDUSTRIAL PARK LEICESTER X0 LE5 1QZ UNITED KINGDOM 0 1 0 0 Sr. V. P., Isomedix & Life Sci Ordinary Shares, 0.10 par value 2016-12-08 4 M 0 2225 29.94 A 20025 D Ordinary Shares, 0.10 par value 2016-12-08 4 S 0 2225 67.5383 D 17800 D Employee Stock Option (right to buy) 29.94 2016-12-08 4 M 0 2225 D 2022-05-30 Ordinary Shares, 0.10 2225 0 D This represents the average sales price of the 2,225 shares sold in the open market. The actual sales prices ranged from $67.50 per share to $67.72 per share. Issuer, upon request by the SEC staff, will provide full information regarding the number of shares sold at each of these eight sales prices. 17,800 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 3,300 on May 31, 2017; 4,000 on May 30, 2018, 5,000 on May 28, 2019, 3,000 on October 1, 2019 and 2,500 on June 1, 2020. This option is fully exercisable. This option was received in the merger in exchange for an option to purchase 2,225 STERIS common shares for $29.94 per share, subject to the same terms and conditions as the original STERIS stock option. /s/ Ronald E. Snyder, Authorized Representative under Power of Attorney 2016-12-09