CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (24,607)	$ (37,542)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization of property and equipment	538	634
Amortization of intangible assets	135	147
Foreign exchange gain	(50,072)	(7,611)
Stock-based compensation expense	11,996	7,959
Amortization of discount on investments	504	48
Deferred tax expense	176	270
Changes in operating assets and liabilities:
Accounts receivable	2,014	(2,097)
Operating lease right-of-use assets and lease obligations	18	(11)
Prepaid expenses and other current assets	4,014	(1,852)
Accounts payable	(6,068)	3,190
Accrued expenses and other liabilities	486	3,207
Deferred revenue	(17,265)	28,704
Net cash provided by (used in) operating activities	(78,131)	(4,954)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of marketable securities	(120,006)	(24,850)
Proceeds from maturities of marketable securities	126,293	28,163
Purchases of property and equipment	(3,200)	(260)
Net cash provided by investing activities	3,087	3,053
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of common stock, net	48,015	129,398
Proceeds from stock options exercised	1,063	6,728
Repurchase of restricted stock units	0	(285)
Net cash provided by financing activities	49,078	152,318
Foreign exchange impact on cash, cash equivalents and restricted cash	(1,176)	(2,027)
Net increase (decrease) in cash, cash equivalents and restricted cash	(27,142)	148,390
Cash, cash equivalents, and restricted cash, beginning of period	241,749	163,283
Cash, cash equivalents, and restricted cash, end of period	214,607	311,673
SUPPLEMENTAL DISCLOSURES:
Lease liabilities arising from obtaining right-of-use assets	11,493	1,662
Income taxes paid	0	491
Non-cash purchases of property, equipment and intangibles	616	22
Non-cash issuance of stock options	0	573
CASH, CASH EQUIVALENTS AND RESTRICTED CASH
Cash and cash equivalents	213,930	311,472
Restricted cash included in non-current other assets	677	201
Cash, cash equivalents, and restricted cash, end of period	214,607	311,673
Lilly
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of common stock, net	$ 0	$ 16,477