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Supplemental Balance Sheet Information - Prepaid expenses and other current assets (Details) - USD ($)
$ in Thousands
Jun. 30, 2018
Dec. 31, 2017
Prepaid expenses and other current assets:    
Prepaid research and development costs $ 41,723 $ 21,156
Prepaid taxes 14,469 9,894
Interest receivable 1,791 1,557
Other 5,310 3,016
Total $ 63,293 $ 35,623