Selected quarterly financial data (unaudited) (Tables)

12 Months Ended

Dec. 31, 2016

Selected quarterly financial data (unaudited)

Schedule of selected quarterly financial data (unaudited)

	Quarter Ended
	March 31			June 30			September 30			December 31
2016
Revenue		677			393			—			—
Loss from operations		(20,334	)		(24,628	)		(34,828	)		(37,270	)
Net loss		(22,001	)		(24,124	)		(35,494	)		(37,598	)
Net loss attributable to ordinary shareholders		(22,001	)		(24,124	)		(35,494	)		(37,598	)
Basic and diluted net loss per share(1)		(0.07	)		(0.06	)		(0.08	)		(0.08	)

	Quarter Ended
	March 31			June 30			September 30			December 31
2015
Revenue		1,379			1,380			1,380			4,677
Loss from operations		(9,812	)		(6,565	)		(13,992	)		(26,376	)
Net loss		(10,212	)		(5,641	)		(13,999	)		(27,250	)
Net loss attributable to ordinary shareholders		(10,212	)		(5,641	)		(13,999	)		(27,250	)
Basic and diluted net loss per share(1)		(0.09	)		(0.05	)		(0.13	)		(0.23	)

(1)           Per common share amounts for the quarters and full years have been calculated separately. Accordingly, the sum of quarterly amounts may not equal the annual amount because of differences in the weighted average common shares outstanding during each period, principally due to the effect of share issuances by the Company during the year.