Stock-based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Stock-based compensation disclosures
Compensation expense	$ 5,881	$ 10,012	$ 23,930	$ 35,742
Research and development
Stock-based compensation disclosures
Compensation expense	3,045	4,552	9,803	12,689
General and administrative
Stock-based compensation disclosures
Compensation expense	$ 2,836	$ 5,460	$ 14,127	$ 23,053