<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
	<headerData>
        <submissionType>144</submissionType>
                <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001742084</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
        <liveTestFlag>LIVE</liveTestFlag>




                </filerInfo>
    </headerData>

     <formData>
        <issuerInfo>
            <issuerCik>0001650664</issuerCik>
			<issuerName>EDITAS MEDICINE, INC.</issuerName>


			    <secFileNumber>001-37687</secFileNumber>


			<issuerAddress>
				<com:street1>c/o Editas Medicine, Inc.</com:street1>
                				<com:street2>11 Hurley St.</com:street2>
                				<com:city>Cambridge</com:city>
				<com:stateOrCountry>MA</com:stateOrCountry>
				<com:zipCode>02141</com:zipCode>
			</issuerAddress>

			<issuerContactPhone>617-401-9000</issuerContactPhone>
			<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Gilmore Neil O'Neill</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>

			<relationshipsToIssuer>

				    <relationshipToIssuer>Officer</relationshipToIssuer>
                                				    <relationshipToIssuer>Director</relationshipToIssuer>

			</relationshipsToIssuer>
		</issuerInfo>

				          <securitiesInformation>
			<securitiesClassTitle>Common Stock</securitiesClassTitle>
			<brokerOrMarketmakerDetails>
				<name>E*Trade Financial Corporation</name>
				<address>
				<com:street1>3 Edison Drive</com:street1>
                				<com:city>Alphareta</com:city>
				<com:stateOrCountry>GA</com:stateOrCountry>
				<com:zipCode>30005</com:zipCode>
				</address>
			</brokerOrMarketmakerDetails>
			<noOfUnitsSold>8500</noOfUnitsSold>
			<aggregateMarketValue>78030</aggregateMarketValue>
			<noOfUnitsOutstanding>68995606</noOfUnitsOutstanding>
			<approxSaleDate>06/05/2023</approxSaleDate>
			<securitiesExchangeName>NASDAQ</securitiesExchangeName>
		</securitiesInformation>

    		       <securitiesToBeSold>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <acquiredDate>06/02/2023</acquiredDate>
         <natureOfAcquisitionTransaction>Restricted Stock Unit Vesting</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer </nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>21664</amountOfSecuritiesAcquired>
                  <paymentDate>06/02/2023</paymentDate>
                  <natureOfPayment>Equity Compensation</natureOfPayment>
      </securitiesToBeSold>

    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>



        <noticeSignature>
            <noticeDate>06/02/2023</noticeDate>
                        <planAdoptionDates>
		                                     <planAdoptionDate>04/13/2022</planAdoptionDate>

            </planAdoptionDates>
                        <signature>  /s/ Gilmore O'Neill</signature>
        </noticeSignature>
	</formData>
    </edgarSubmission>
