X0306 4 2015-11-02 0 0001348911 Carbylan Therapeutics, Inc. CBYL 0001650427 McKune John C/O CARBYLAN THERAPEUTICS, INC. 3181 PORTER DRIVE PALO ALTO CA 94304 0 1 0 0 See Remarks Stock Option (Right to Buy) 4.01 2015-11-02 4 A 0 50000 0.00 A 2025-11-02 Common Stock 50000 50000 D The option shall vest with respect to one-quarter of the underlying shares upon the first anniversary of the vesting commencement date of August 5, 2015, and then with respect to the remaining shares monthly thereafter over the next three years. Corporate Controller & Principal Accounting Officer By: /s/ David J. Saul, Attorney-in-fact 2015-11-04