X0306 4 2022-03-31 0 0001649989 Outlook Therapeutics, Inc. OTLK 0001227307 TRENARY C RUSSELL III 485 ROUTE 1 SOUTH, BUILDING F SUITE 320 ISELIN NJ 08830 1 1 0 0 CEO and President Stock Option (Right to Buy) 1.44 2022-03-31 4 A 0 500000 0.00 A 2031-12-21 Common Stock 500000 500000 D Represents the number of shares that vested under a performance-based stock option grant based on the Issuer's satisfaction of certain performance criteria. In light of the performance-based vesting conditions of the option, such shares were not reportable under Section 16 until vesting was determined, which occurred on March 31, 2022. The vested shares represents the first of four possible vesting events of the total number of shares subject to the option. The remaining shares subject to the option will vest only upon the satisfaction of additional performance vesting criteria. Fully vested and immediately exercisable. /s/ Lawrence Kenyon, Attorney-in-Fact 2022-04-04