X0306 4 2022-03-23 0 0001649989 Outlook Therapeutics, Inc. OTLK 0001649867 Auffarth Gerd C/O OUTLOOK THERAPEUTICS, INC. 485 ROUTE 1 SOUTH, BUILDING F, SUITE 320 ISELIN NJ 08830 1 0 0 0 Stock Option (Right to Buy) 1.92 2022-03-23 4 A 0 21878 0.00 A 2032-03-23 Common Stock 21878 21878 D The options were granted under the Issuer's 2015 Equity Incentive Plan (the "2015 Plan") and shall fully vest on the earlier of (i) March 23,2023; or (ii) the date of the Issuer's next annual meeting of stockholders, in each case subject to the Reporting Person providing continuous service to the Issuer on such date. In addition, the shares underlying the options are subject to acceleration upon a Change in Control as defined in the 2015 Plan, subject to the Reporting Person providing continuous service to the Issuer immediately prior to such Change in Control. /s/ Lawrence Kenyon, Attorney-in-Fact 2022-03-24