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Pay vs Performance Disclosure - USD ($)

12 Months Ended

Dec. 31, 2024

Dec. 31, 2023

Dec. 31, 2022

Dec. 31, 2021

Pay vs Performance Disclosure

Pay vs Performance Disclosure, Table


						Average
						Summary		Average		Value of Initial Fixed $100
		Summary				Compensation		Compensation		Investment Based on:
		Compensation		Compensation		Table Total		Actually Paid		Total		Peer Group
		Table Total		Actually Paid		for Non-PEO		to Non-PEO		Shareholder		Total Shareholder		Net Income		Total Revenues
Year		for PEO ($)		to PEO ($)(1)		NEOs ($)		NEOs ($)(1)		Return ($)		Return ($)(2)		($)		($)(3)
2024		14,663,742		18,680,784		4,600,098		6,662,641		188.27		93.49		(260,602)		130,126
2023		7,230,457		19,005,711		1,974,174		4,813,432		154.61		94.03		(184,678)		77,428
2022		3,325,758		24,142,912		1,110,455		4,805,393		97.94		89.90		(181,119)		23,638
2021		6,458,360		(10,017,699)		2,069,493		(775,040)		33.57		100.02		(69,612)		3,154

(1)	Amounts represent compensation actually paid to our PEO and the average compensation actually paid to our remaining NEOs for the relevant fiscal year, as determined under SEC rules (and described in Note 2 below), which includes the individuals indicated in the table below for each fiscal year:


Year		PEO		Non-PEO NEOs
2024		David P. Meeker		Hunter C. Smith, Jennifer Lee, Yann Mazabraud and Joseph Shulman
2023		David P. Meeker		Hunter C. Smith, Jennifer Lee, Yann Mazabraud and Joseph Shulman
2022		David P. Meeker		Hunter C. Smith, Jennifer Lee, Yann Mazabraud and Joseph Shulman
2021		David P. Meeker		Hunter C. Smith, Murray Stewart, Jennifer Lee, Yann Mazabraud and Joseph Shulman

The 2024 Summary Compensation Table totals reported for the PEO and the average of the Other NEOs for each year were subject to the following adjustments per Item 402(v)(2)(iii) of Regulation S-K to calculate “compensation actually paid”:


		2024
				Average for
		PEO		Other NEO’s
Summary Compensation Table Total		14,663,742		4,600,098
ADJUSTMENTS(a):
Deduction for Amounts reported under the “Stock Awards” and “Option Awards” Columns in the Summary Compensation Table(a)		(13,167,070)		(3,661,679)
Increase based on ASC 718 Fair Value of Awards Granted during Applicable FY that Remain Unvested as of Applicable FY End, determined as of Applicable FY End		14,814,603		5,167,345
Increase based on ASC 718 Fair Value of Awards Granted during Applicable FY that Vested during Applicable FY, determined as of Vesting Date		1,446,713		369,568
Increase/deduction for Awards Granted during Prior FY that were Outstanding and Unvested as of Applicable FY End, determined based on change in ASC 718 Fair Value from Prior FY End to Applicable FY End		3,068,264		620,657
Increase/deduction for Awards Granted during Prior FY that Vested During Applicable FY, determined based on change in ASC 718 Fair Value from Prior FY End to Vesting Date		(805,993)		112,541
Deduction of ASC 718 Fair Value of Awards Granted during Prior FY that were Forfeited during Applicable FY, determined as of Prior FY End (a)		(1,339,475)		(545,891)
Increase based on Dividends or Other Earnings Paid during Applicable FY prior to Vesting Date (b)		—		—
Increase based on Incremental Fair Value of Options/SARs Modified during Applicable FY		—		—
Adjustments Related to Defined Benefit and Actuarial Pension Plans (c)		—		—
Compensation Actually Paid		18,680,784		6,662,641

(a)

During FY 2024, certain PSUs issued to PEOs and NEOs in 2021 were forfeited due to non-fulfillment of performance standards. Additionally, Yann Mazabraud’s unvested RSUs were forfeited.

(b)

No Dividends or Other Earnings were paid during the years presented above prior to Vesting Dates.

(c)

The pensions adjustment is not applicable for the years presented above.

Measurement date equity fair values are calculated with assumptions derived on a basis consistent with those used for grant date fair value purposes. RSUs and PSUs are valued based on the closing stock price on the relevant measurement date. Stock options are valued using a Black-Scholes model as at the relevant measurement dates.

(2)For the relevant fiscal year, represents the cumulative TSR (the “Peer Group TSR”) of the NASDAQ Biotechnology Index (the “Peer Group”). The dollar amounts reported represent the amount of net loss reflected in the Company's audited financial statements for the applicable fiscal year.

(3)	Revenue is the Company’s selected GAAP measure.

Company Selected Measure Name

Total Revenues

Named Executive Officers, Footnote

(1)	Amounts represent compensation actually paid to our PEO and the average compensation actually paid to our remaining NEOs for the relevant fiscal year, as determined under SEC rules (and described in Note 2 below), which includes the individuals indicated in the table below for each fiscal year:


Year		PEO		Non-PEO NEOs
2024		David P. Meeker		Hunter C. Smith, Jennifer Lee, Yann Mazabraud and Joseph Shulman
2023		David P. Meeker		Hunter C. Smith, Jennifer Lee, Yann Mazabraud and Joseph Shulman
2022		David P. Meeker		Hunter C. Smith, Jennifer Lee, Yann Mazabraud and Joseph Shulman
2021		David P. Meeker		Hunter C. Smith, Murray Stewart, Jennifer Lee, Yann Mazabraud and Joseph Shulman

Peer Group Issuers, Footnote

(2)For the relevant fiscal year, represents the cumulative TSR (the “Peer Group TSR”) of the NASDAQ Biotechnology Index (the “Peer Group”). The dollar amounts reported represent the amount of net loss reflected in the Company's audited financial statements for the applicable fiscal year.

PEO Total Compensation Amount

$ 14,663,742

$ 7,230,457

$ 3,325,758

$ 6,458,360

PEO Actually Paid Compensation Amount

$ 18,680,784

19,005,711

24,142,912

(10,017,699)

Adjustment To PEO Compensation, Footnote

The 2024 Summary Compensation Table totals reported for the PEO and the average of the Other NEOs for each year were subject to the following adjustments per Item 402(v)(2)(iii) of Regulation S-K to calculate “compensation actually paid”:


		2024
				Average for
		PEO		Other NEO’s
Summary Compensation Table Total		14,663,742		4,600,098
ADJUSTMENTS(a):
Deduction for Amounts reported under the “Stock Awards” and “Option Awards” Columns in the Summary Compensation Table(a)		(13,167,070)		(3,661,679)
Increase based on ASC 718 Fair Value of Awards Granted during Applicable FY that Remain Unvested as of Applicable FY End, determined as of Applicable FY End		14,814,603		5,167,345
Increase based on ASC 718 Fair Value of Awards Granted during Applicable FY that Vested during Applicable FY, determined as of Vesting Date		1,446,713		369,568
Increase/deduction for Awards Granted during Prior FY that were Outstanding and Unvested as of Applicable FY End, determined based on change in ASC 718 Fair Value from Prior FY End to Applicable FY End		3,068,264		620,657
Increase/deduction for Awards Granted during Prior FY that Vested During Applicable FY, determined based on change in ASC 718 Fair Value from Prior FY End to Vesting Date		(805,993)		112,541
Deduction of ASC 718 Fair Value of Awards Granted during Prior FY that were Forfeited during Applicable FY, determined as of Prior FY End (a)		(1,339,475)		(545,891)
Increase based on Dividends or Other Earnings Paid during Applicable FY prior to Vesting Date (b)		—		—
Increase based on Incremental Fair Value of Options/SARs Modified during Applicable FY		—		—
Adjustments Related to Defined Benefit and Actuarial Pension Plans (c)		—		—
Compensation Actually Paid		18,680,784		6,662,641

(a)

During FY 2024, certain PSUs issued to PEOs and NEOs in 2021 were forfeited due to non-fulfillment of performance standards. Additionally, Yann Mazabraud’s unvested RSUs were forfeited.

(b)

No Dividends or Other Earnings were paid during the years presented above prior to Vesting Dates.

(c)

The pensions adjustment is not applicable for the years presented above.

Non-PEO NEO Average Total Compensation Amount

$ 4,600,098

1,974,174

1,110,455

2,069,493

Non-PEO NEO Average Compensation Actually Paid Amount

$ 6,662,641

4,813,432

4,805,393

(775,040)

Adjustment to Non-PEO NEO Compensation Footnote

The 2024 Summary Compensation Table totals reported for the PEO and the average of the Other NEOs for each year were subject to the following adjustments per Item 402(v)(2)(iii) of Regulation S-K to calculate “compensation actually paid”:


		2024
				Average for
		PEO		Other NEO’s
Summary Compensation Table Total		14,663,742		4,600,098
ADJUSTMENTS(a):
Deduction for Amounts reported under the “Stock Awards” and “Option Awards” Columns in the Summary Compensation Table(a)		(13,167,070)		(3,661,679)
Increase based on ASC 718 Fair Value of Awards Granted during Applicable FY that Remain Unvested as of Applicable FY End, determined as of Applicable FY End		14,814,603		5,167,345
Increase based on ASC 718 Fair Value of Awards Granted during Applicable FY that Vested during Applicable FY, determined as of Vesting Date		1,446,713		369,568
Increase/deduction for Awards Granted during Prior FY that were Outstanding and Unvested as of Applicable FY End, determined based on change in ASC 718 Fair Value from Prior FY End to Applicable FY End		3,068,264		620,657
Increase/deduction for Awards Granted during Prior FY that Vested During Applicable FY, determined based on change in ASC 718 Fair Value from Prior FY End to Vesting Date		(805,993)		112,541
Deduction of ASC 718 Fair Value of Awards Granted during Prior FY that were Forfeited during Applicable FY, determined as of Prior FY End (a)		(1,339,475)		(545,891)
Increase based on Dividends or Other Earnings Paid during Applicable FY prior to Vesting Date (b)		—		—
Increase based on Incremental Fair Value of Options/SARs Modified during Applicable FY		—		—
Adjustments Related to Defined Benefit and Actuarial Pension Plans (c)		—		—
Compensation Actually Paid		18,680,784		6,662,641

(a)

During FY 2024, certain PSUs issued to PEOs and NEOs in 2021 were forfeited due to non-fulfillment of performance standards. Additionally, Yann Mazabraud’s unvested RSUs were forfeited.

(b)

No Dividends or Other Earnings were paid during the years presented above prior to Vesting Dates.

(c)

The pensions adjustment is not applicable for the years presented above.

Compensation Actually Paid vs. Total Shareholder Return

Compensation Actually Paid vs. Net Income

Tabular List, Table

Pay Versus Performance Tabular List

We believe the following performance measures represent the most important financial performance measures used by us to link compensation actually paid to our NEOs for the fiscal year ended December 31, 2024:

●

Total revenues;

●

Total shareholders return; and

●

Cash used in operations.

Total Shareholder Return Amount

$ 188.27

154.61

97.94

33.57

Peer Group Total Shareholder Return Amount

93.49

94.03

89.9

100.02

Net Income (Loss)

$ (260,602)

$ (184,678)

$ (181,119)

$ (69,612)

Company Selected Measure Amount

130,126

77,428

23,638

3,154

David P. Meeker

Equity Awards Adjustments, Footnote

Measurement date equity fair values are calculated with assumptions derived on a basis consistent with those used for grant date fair value purposes. RSUs and PSUs are valued based on the closing stock price on the relevant measurement date. Stock options are valued using a Black-Scholes model as at the relevant measurement dates.

Pay vs Performance Disclosure

Total revenues

Non-GAAP Measure Description

(3)	Revenue is the Company’s selected GAAP measure.

Pay vs Performance Disclosure

Total shareholders return

Pay vs Performance Disclosure

Cash used in operations

PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

$ (13,167,070)

PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

14,814,603

PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

3,068,264

PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

1,446,713

PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(805,993)

PEO | Equity Award Adjustment, Deduction in Fair Value of Awards Granted during Prior FY that were Forfeited during Applicable FY, determined as of Prior FY End [Member]

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(1,339,475)

Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(3,661,679)

Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

5,167,345

Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

620,657

Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

369,568

Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

112,541

Non-PEO NEO | Equity Award Adjustment, Deduction in Fair Value of Awards Granted during Prior FY that were Forfeited during Applicable FY, determined as of Prior FY End [Member]

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

$ (545,891)