X0206 3 2017-10-04 0 0001649904 RHYTHM PHARMACEUTICALS, INC. RYTM 0001657185 Fiedorek Fred T. 500 BOYLSTON STREET, 11TH FLOOR BOSTON MA 02116 0 1 0 0 Chief Medical Officer Common Stock 131899 D Employee Stock Option (Right to Buy) 4.59 2025-11-16 Common Stock 79816 D Employee Stock Option (Right to Buy) 7.52 2025-12-30 Common Stock 9814 D Employee Stock Option (Right to Buy) 6.14 2027-04-04 Common Stock 10905 D The stock options vest and become exercisable in 48 successive, equal monthly installments measured from August 3, 2015. The stock options vest and become exercisable in 48 successive, equal monthly installments measured from August 3, 2015. The stock options vest and become exercisable in 48 successive, equal monthly installments measured from January 6, 2017. Exhibit List Exhibit 24 - Power of Attorney /s/Keith M. Gottesdiener 2017-10-04