<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001258693</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001649094</issuerCik>
      <issuerName>Vaxcyte, Inc.</issuerName>
      <secFileNumber>001-39323</secFileNumber>
      <issuerAddress>
        <com:street1>825 INDUSTRIAL ROAD, STE. 300</com:street1>
        <com:city>SAN CARLOS</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94070</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>650-837-0111</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PICKERING GRANT</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>UBS Financial Services, Inc.</name>
        <address>
          <com:street1>11 Madison Ave</com:street1>
          <com:street2>4th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10010</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>18198</noOfUnitsSold>
      <aggregateMarketValue>996704.46</aggregateMarketValue>
      <noOfUnitsOutstanding>144397682</noOfUnitsOutstanding>
      <approxSaleDate>07/27/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/27/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Exercise of Stock Options</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>16198</amountOfSecuritiesAcquired>
      <paymentDate>07/27/2026</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/09/2013</acquiredDate>
      <natureOfAcquisitionTransaction>Founder Shares</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2000</amountOfSecuritiesAcquired>
      <paymentDate>12/09/2013</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Grant Pickering</name>
        <address>
          <com:street1>825 INDUSTRIAL ROAD, STE. 300</com:street1>
          <com:city>SAN CARLOS</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/18/2026</saleDate>
      <amountOfSecuritiesSold>22461</amountOfSecuritiesSold>
      <grossProceeds>1179204.75</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Claire Pickering 2020 Delaware Trust</name>
        <address>
          <com:street1>825 INDUSTRIAL ROAD, STE. 300</com:street1>
          <com:city>SAN CARLOS</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/18/2026</saleDate>
      <amountOfSecuritiesSold>1000</amountOfSecuritiesSold>
      <grossProceeds>52500.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Benjamin Pickering 2020 Delaware Trust</name>
        <address>
          <com:street1>825 INDUSTRIAL ROAD, STE. 300</com:street1>
          <com:city>SAN CARLOS</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/18/2026</saleDate>
      <amountOfSecuritiesSold>1000</amountOfSecuritiesSold>
      <grossProceeds>52500.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Grant Pickering</name>
        <address>
          <com:street1>825 INDUSTRIAL ROAD, STE. 300</com:street1>
          <com:city>SAN CARLOS</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/26/2026</saleDate>
      <amountOfSecuritiesSold>22237</amountOfSecuritiesSold>
      <grossProceeds>1227807.06</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Claire Pickering 2020 Delaware Trust</name>
        <address>
          <com:street1>825 INDUSTRIAL ROAD, STE. 300</com:street1>
          <com:city>SAN CARLOS</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/26/2026</saleDate>
      <amountOfSecuritiesSold>1000</amountOfSecuritiesSold>
      <grossProceeds>55259.30</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Benjamin Pickering 2020 Delaware Trust</name>
        <address>
          <com:street1>825 INDUSTRIAL ROAD, STE. 300</com:street1>
          <com:city>SAN CARLOS</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/26/2026</saleDate>
      <amountOfSecuritiesSold>1000</amountOfSecuritiesSold>
      <grossProceeds>55206.20</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>16,198 shares represented in this filing are being sold under Grant Pickering, 1,000 shares are being sold under the Claire Pickering 2020 Delaware Trust and 1,000 shares are being sold under the Benjamin Pickering 2020Delaware Trust.</remarks>
    <noticeSignature>
      <noticeDate>07/27/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>03/03/2026</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ UBS Financial Services Inc, as attorney-in-fact for Grant Pickering</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
