3.25.4 html 265 422 1 false 76 0 false 8 false false R1.htm 0000001 - Document - Cover Sheet http://www.vaxcyte.com/role/Cover Cover Cover 1 false false R2.htm 0000002 - Document - Audit Information Sheet http://www.vaxcyte.com/role/AuditInformation Audit Information Cover 2 false false R3.htm 9952151 - Statement - Consolidated Balance Sheets Sheet http://www.vaxcyte.com/role/ConsolidatedBalanceSheets Consolidated Balance Sheets Statements 3 false false R4.htm 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) Sheet http://www.vaxcyte.com/role/ConsolidatedBalanceSheetsParenthetical Consolidated Balance Sheets (Parenthetical) Statements 4 false false R5.htm 9952153 - Statement - Consolidated Statements of Operations Sheet http://www.vaxcyte.com/role/ConsolidatedStatementsofOperations Consolidated Statements of Operations Statements 5 false false R6.htm 9952154 - Statement - Consolidated Statements of Comprehensive Loss Sheet http://www.vaxcyte.com/role/ConsolidatedStatementsofComprehensiveLoss Consolidated Statements of Comprehensive Loss Statements 6 false false R7.htm 9952155 - Statement - Consolidated Statements of Stockholders??? Equity Sheet http://www.vaxcyte.com/role/ConsolidatedStatementsofStockholdersEquity Consolidated Statements of Stockholders??? Equity Statements 7 false false R8.htm 9952156 - Statement - Consolidated Statements of Stockholders??? Equity (Parenthetical) Sheet http://www.vaxcyte.com/role/ConsolidatedStatementsofStockholdersEquityParenthetical Consolidated Statements of Stockholders??? Equity (Parenthetical) Statements 8 false false R9.htm 9952157 - Statement - Consolidated Statements of Cash Flows Sheet http://www.vaxcyte.com/role/ConsolidatedStatementsofCashFlows Consolidated Statements of Cash Flows Statements 9 false false R10.htm 9952158 - Disclosure - Company Organization and Nature of Business Sheet http://www.vaxcyte.com/role/CompanyOrganizationandNatureofBusiness Company Organization and Nature of Business Notes 10 false false R11.htm 9952159 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies Sheet http://www.vaxcyte.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies Basis of Presentation and Summary of Significant Accounting Policies Notes 11 false false R12.htm 9952160 - Disclosure - Fair Value Measurements and Fair Value of Financial Instruments Sheet http://www.vaxcyte.com/role/FairValueMeasurementsandFairValueofFinancialInstruments Fair Value Measurements and Fair Value of Financial Instruments Notes 12 false false R13.htm 9952161 - Disclosure - Commercial Manufacturing and Supply Agreement Sheet http://www.vaxcyte.com/role/CommercialManufacturingandSupplyAgreement Commercial Manufacturing and Supply Agreement Notes 13 false false R14.htm 9952162 - Disclosure - Balance Sheet Details Sheet http://www.vaxcyte.com/role/BalanceSheetDetails Balance Sheet Details Notes 14 false false R15.htm 9952163 - Disclosure - Leases Sheet http://www.vaxcyte.com/role/Leases Leases Notes 15 false false R16.htm 9952164 - Disclosure - Commitments and Contingencies Sheet http://www.vaxcyte.com/role/CommitmentsandContingencies Commitments and Contingencies Notes 16 false false R17.htm 9952165 - Disclosure - Stockholders' Equity Sheet http://www.vaxcyte.com/role/StockholdersEquity Stockholders' Equity Notes 17 false false R18.htm 9952166 - Disclosure - Equity Incentive Plans Sheet http://www.vaxcyte.com/role/EquityIncentivePlans Equity Incentive Plans Notes 18 false false R19.htm 9952167 - Disclosure - Funding Arrangement Sheet http://www.vaxcyte.com/role/FundingArrangement Funding Arrangement Notes 19 false false R20.htm 9952168 - Disclosure - Net Loss Per Share Sheet http://www.vaxcyte.com/role/NetLossPerShare Net Loss Per Share Notes 20 false false R21.htm 9952169 - Disclosure - Income Taxes Sheet http://www.vaxcyte.com/role/IncomeTaxes Income Taxes Notes 21 false false R22.htm 9952170 - Disclosure - Segment Reporting Sheet http://www.vaxcyte.com/role/SegmentReporting Segment Reporting Notes 22 false false R23.htm 9952171 - Disclosure - Subsequent Events Sheet http://www.vaxcyte.com/role/SubsequentEvents Subsequent Events Notes 23 false false R24.htm 995445 - Disclosure - Insider Trading Arrangements Sheet http://xbrl.sec.gov/ecd/role/InsiderTradingArrangements Insider Trading Arrangements Notes 24 false false R25.htm 995447 - Disclosure - Insider Trading Policies and Procedures Sheet http://xbrl.sec.gov/ecd/role/InsiderTradingPoliciesProc Insider Trading Policies and Procedures Notes 25 false false R26.htm 995550 - Disclosure - Cybersecurity Risk Management and Strategy Disclosure Sheet http://xbrl.sec.gov/cyd/role/CybersecurityRiskManagementAndStrategyDisclosure Cybersecurity Risk Management and Strategy Disclosure Notes 26 false false R27.htm 9955511 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Policies) Sheet http://www.vaxcyte.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies Basis of Presentation and Summary of Significant Accounting Policies (Policies) Policies http://www.vaxcyte.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies 27 false false R28.htm 9955512 - Disclosure - Fair Value Measurements and Fair Value of Financial Instruments (Tables) Sheet http://www.vaxcyte.com/role/FairValueMeasurementsandFairValueofFinancialInstrumentsTables Fair Value Measurements and Fair Value of Financial Instruments (Tables) Tables http://www.vaxcyte.com/role/FairValueMeasurementsandFairValueofFinancialInstruments 28 false false R29.htm 9955513 - Disclosure - Balance Sheet Details (Tables) Sheet http://www.vaxcyte.com/role/BalanceSheetDetailsTables Balance Sheet Details (Tables) Tables http://www.vaxcyte.com/role/BalanceSheetDetails 29 false false R30.htm 9955514 - Disclosure - Leases (Tables) Sheet http://www.vaxcyte.com/role/LeasesTables Leases (Tables) Tables http://www.vaxcyte.com/role/Leases 30 false false R31.htm 9955515 - Disclosure - Commitments and Contingencies (Table) Sheet http://www.vaxcyte.com/role/CommitmentsandContingenciesTable Commitments and Contingencies (Table) Tables http://www.vaxcyte.com/role/CommitmentsandContingencies 31 false false R32.htm 9955516 - Disclosure - Stockholders' Equity (Tables) Sheet http://www.vaxcyte.com/role/StockholdersEquityTables Stockholders' Equity (Tables) Tables http://www.vaxcyte.com/role/StockholdersEquity 32 false false R33.htm 9955517 - Disclosure - Equity Incentive Plans (Tables) Sheet http://www.vaxcyte.com/role/EquityIncentivePlansTables Equity Incentive Plans (Tables) Tables http://www.vaxcyte.com/role/EquityIncentivePlans 33 false false R34.htm 9955518 - Disclosure - Net Loss Per Share (Tables) Sheet http://www.vaxcyte.com/role/NetLossPerShareTables Net Loss Per Share (Tables) Tables http://www.vaxcyte.com/role/NetLossPerShare 34 false false R35.htm 9955519 - Disclosure - Income Taxes (Tables) Sheet http://www.vaxcyte.com/role/IncomeTaxesTables Income Taxes (Tables) Tables http://www.vaxcyte.com/role/IncomeTaxes 35 false false R36.htm 9955520 - Disclosure - Segment Reporting (Tables) Sheet http://www.vaxcyte.com/role/SegmentReportingTables Segment Reporting (Tables) Tables http://www.vaxcyte.com/role/SegmentReporting 36 false false R37.htm 9955521 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Details) Sheet http://www.vaxcyte.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDetails Basis of Presentation and Summary of Significant Accounting Policies (Details) Details http://www.vaxcyte.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies 37 false false R38.htm 9955522 - Disclosure - Fair Value Measurements and Fair Value of Financial Instruments - Schedule of Financial Instruments Measured at Fair Value on Recurring Basis (Details) Sheet http://www.vaxcyte.com/role/FairValueMeasurementsandFairValueofFinancialInstrumentsScheduleofFinancialInstrumentsMeasuredatFairValueonRecurringBasisDetails Fair Value Measurements and Fair Value of Financial Instruments - Schedule of Financial Instruments Measured at Fair Value on Recurring Basis (Details) Details 38 false false R39.htm 9955523 - Disclosure - Fair Value Measurements and Fair Value of Financial Instruments - Additional Information (Details) Sheet http://www.vaxcyte.com/role/FairValueMeasurementsandFairValueofFinancialInstrumentsAdditionalInformationDetails Fair Value Measurements and Fair Value of Financial Instruments - Additional Information (Details) Details 39 false false R40.htm 9955524 - Disclosure - Fair Value Measurements and Fair Value of Financial Instruments - Schedule of Contractual Maturities of Investments (Details) Sheet http://www.vaxcyte.com/role/FairValueMeasurementsandFairValueofFinancialInstrumentsScheduleofContractualMaturitiesofInvestmentsDetails Fair Value Measurements and Fair Value of Financial Instruments - Schedule of Contractual Maturities of Investments (Details) Details 40 false false R41.htm 9955525 - Disclosure - Commercial Manufacturing and Supply Agreement (Details) Sheet http://www.vaxcyte.com/role/CommercialManufacturingandSupplyAgreementDetails Commercial Manufacturing and Supply Agreement (Details) Details http://www.vaxcyte.com/role/CommercialManufacturingandSupplyAgreement 41 false false R42.htm 9955526 - Disclosure - Balance Sheet Details - Schedule of Prepaid Expenses and Other Current Assets (Details) Sheet http://www.vaxcyte.com/role/BalanceSheetDetailsScheduleofPrepaidExpensesandOtherCurrentAssetsDetails Balance Sheet Details - Schedule of Prepaid Expenses and Other Current Assets (Details) Details 42 false false R43.htm 9955527 - Disclosure - Balance Sheet Details - Schedule of Property and Equipment, Net (Details) Sheet http://www.vaxcyte.com/role/BalanceSheetDetailsScheduleofPropertyandEquipmentNetDetails Balance Sheet Details - Schedule of Property and Equipment, Net (Details) Details 43 false false R44.htm 9955528 - Disclosure - Balance Sheet Details - Additional Information (Details) Sheet http://www.vaxcyte.com/role/BalanceSheetDetailsAdditionalInformationDetails Balance Sheet Details - Additional Information (Details) Details 44 false false R45.htm 9955529 - Disclosure - Balance Sheet Details - Summary of Other Assets (Details) Sheet http://www.vaxcyte.com/role/BalanceSheetDetailsSummaryofOtherAssetsDetails Balance Sheet Details - Summary of Other Assets (Details) Details 45 false false R46.htm 9955530 - Disclosure - Balance Sheet Details - Schedule of Accrued Expenses (Details) Sheet http://www.vaxcyte.com/role/BalanceSheetDetailsScheduleofAccruedExpensesDetails Balance Sheet Details - Schedule of Accrued Expenses (Details) Details 46 false false R47.htm 9955531 - Disclosure - Leases - Additional Information (Details) Sheet http://www.vaxcyte.com/role/LeasesAdditionalInformationDetails Leases - Additional Information (Details) Details 47 false false R48.htm 9955532 - Disclosure - Leases - Schedule of Information Related to Weighted Averages (Details) Sheet http://www.vaxcyte.com/role/LeasesScheduleofInformationRelatedtoWeightedAveragesDetails Leases - Schedule of Information Related to Weighted Averages (Details) Details 48 false false R49.htm 9955533 - Disclosure - Leases - Schedule of Information Related to ROU Assets and Lease Liabilities (Details) Sheet http://www.vaxcyte.com/role/LeasesScheduleofInformationRelatedtoROUAssetsandLeaseLiabilitiesDetails Leases - Schedule of Information Related to ROU Assets and Lease Liabilities (Details) Details 49 false false R50.htm 9955534 - Disclosure - Leases - Schedule of Maturities of Lease Liabilities (Details) Sheet http://www.vaxcyte.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesDetails Leases - Schedule of Maturities of Lease Liabilities (Details) Details 50 false false R51.htm 9955535 - Disclosure - Commitment and Contingencies - Additional Information (Details) Sheet http://www.vaxcyte.com/role/CommitmentandContingenciesAdditionalInformationDetails Commitment and Contingencies - Additional Information (Details) Details 51 false false R52.htm 9955536 - Disclosure - Commitments and Contingencies - Schedule of Purchase Commitment (Details) Sheet http://www.vaxcyte.com/role/CommitmentsandContingenciesScheduleofPurchaseCommitmentDetails Commitments and Contingencies - Schedule of Purchase Commitment (Details) Details 52 false false R53.htm 9955537 - Disclosure - Stockholders' Equity - Additional Information (Details) Sheet http://www.vaxcyte.com/role/StockholdersEquityAdditionalInformationDetails Stockholders' Equity - Additional Information (Details) Details 53 false false R54.htm 9955538 - Disclosure - Stockholders' Equity - Schedule of Share Activity Under the Amended ATM Sales Agreements (Details) Sheet http://www.vaxcyte.com/role/StockholdersEquityScheduleofShareActivityUndertheAmendedATMSalesAgreementsDetails Stockholders' Equity - Schedule of Share Activity Under the Amended ATM Sales Agreements (Details) Details 54 false false R55.htm 9955539 - Disclosure - Equity Incentive Plans - Additional Information (Details) Sheet http://www.vaxcyte.com/role/EquityIncentivePlansAdditionalInformationDetails Equity Incentive Plans - Additional Information (Details) Details 55 false false R56.htm 9955540 - Disclosure - Equity Incentive Plans - Schedule of Activity Under Stock Option Plans (Details) Sheet http://www.vaxcyte.com/role/EquityIncentivePlansScheduleofActivityUnderStockOptionPlansDetails Equity Incentive Plans - Schedule of Activity Under Stock Option Plans (Details) Details 56 false false R57.htm 9955541 - Disclosure - Equity Incentive Plans - Schedule of Stock Unit Award Activity (Details) Sheet http://www.vaxcyte.com/role/EquityIncentivePlansScheduleofStockUnitAwardActivityDetails Equity Incentive Plans - Schedule of Stock Unit Award Activity (Details) Details 57 false false R58.htm 9955542 - Disclosure - Equity Incentive Plans - Schedule of Share-Based Payment Arrangement, Activity (Details) Sheet http://www.vaxcyte.com/role/EquityIncentivePlansScheduleofShareBasedPaymentArrangementActivityDetails Equity Incentive Plans - Schedule of Share-Based Payment Arrangement, Activity (Details) Details 58 false false R59.htm 9955543 - Disclosure - Equity Incentive Plans - Schedule of Estimated Fair Value of Shares Under Stock-based Compensation Expense (Details) Sheet http://www.vaxcyte.com/role/EquityIncentivePlansScheduleofEstimatedFairValueofSharesUnderStockbasedCompensationExpenseDetails Equity Incentive Plans - Schedule of Estimated Fair Value of Shares Under Stock-based Compensation Expense (Details) Details 59 false false R60.htm 9955544 - Disclosure - Equity Incentive Plans - Schedule of Stock-based Compensation Expense (Details) Sheet http://www.vaxcyte.com/role/EquityIncentivePlansScheduleofStockbasedCompensationExpenseDetails Equity Incentive Plans - Schedule of Stock-based Compensation Expense (Details) Details 60 false false R61.htm 9955545 - Disclosure - Funding Arrangements (Details) Sheet http://www.vaxcyte.com/role/FundingArrangementsDetails Funding Arrangements (Details) Details http://www.vaxcyte.com/role/FundingArrangement 61 false false R62.htm 9955546 - Disclosure - Net Loss Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share (Details) Sheet http://www.vaxcyte.com/role/NetLossPerShareScheduleofComputationofBasicandDilutedNetLossPerShareDetails Net Loss Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share (Details) Details 62 false false R63.htm 9955547 - Disclosure - Net Loss Per Share - Schedule of Potentially Dilutive Securities Excluded From Computation of Diluted Net Loss Per Share Attributable to Common Stockholders (Details) Sheet http://www.vaxcyte.com/role/NetLossPerShareScheduleofPotentiallyDilutiveSecuritiesExcludedFromComputationofDilutedNetLossPerShareAttributabletoCommonStockholdersDetails Net Loss Per Share - Schedule of Potentially Dilutive Securities Excluded From Computation of Diluted Net Loss Per Share Attributable to Common Stockholders (Details) Details 63 false false R64.htm 9955548 - Disclosure - Income Taxes - Additional Information (Details) Sheet http://www.vaxcyte.com/role/IncomeTaxesAdditionalInformationDetails Income Taxes - Additional Information (Details) Details 64 false false R65.htm 9955549 - Disclosure - Income Taxes - Schedule of Reconciliation of Effective Tax Rate (Details) Sheet http://www.vaxcyte.com/role/IncomeTaxesScheduleofReconciliationofEffectiveTaxRateDetails Income Taxes - Schedule of Reconciliation of Effective Tax Rate (Details) Details 65 false false R66.htm 9955550 - Disclosure - Income Taxes - Schedule of Components of Deferred Tax Assets (Details) Sheet http://www.vaxcyte.com/role/IncomeTaxesScheduleofComponentsofDeferredTaxAssetsDetails Income Taxes - Schedule of Components of Deferred Tax Assets (Details) Details 66 false false R67.htm 9955551 - Disclosure - Income Taxes - Schedule of Reconciliation of Unrecognized Tax Benefit (Details) Sheet http://www.vaxcyte.com/role/IncomeTaxesScheduleofReconciliationofUnrecognizedTaxBenefitDetails Income Taxes - Schedule of Reconciliation of Unrecognized Tax Benefit (Details) Details 67 false false R68.htm 9955552 - Disclosure - Segment Reporting - Additional Information (Details) Sheet http://www.vaxcyte.com/role/SegmentReportingAdditionalInformationDetails Segment Reporting - Additional Information (Details) Details 68 false false R69.htm 9955553 - Disclosure - Segment Reporting - Schedule of Disaggregation of Income Statement Expenses (Details) Sheet http://www.vaxcyte.com/role/SegmentReportingScheduleofDisaggregationofIncomeStatementExpensesDetails Segment Reporting - Schedule of Disaggregation of Income Statement Expenses (Details) Details 69 false false R70.htm 9955554 - Disclosure - Subsequent Events (Details) Sheet http://www.vaxcyte.com/role/SubsequentEventsDetails Subsequent Events (Details) Details http://www.vaxcyte.com/role/SubsequentEvents 70 false false All Reports Book All Reports pcvx-20251231.htm pcvx-20251231.xsd pcvx-20251231_cal.xml pcvx-20251231_def.xml pcvx-20251231_lab.xml pcvx-20251231_pre.xml pcvx-20251231_g1.jpg pcvx-20251231_g10.jpg pcvx-20251231_g11.jpg pcvx-20251231_g12.jpg pcvx-20251231_g13.jpg pcvx-20251231_g14.jpg pcvx-20251231_g15.jpg pcvx-20251231_g16.jpg pcvx-20251231_g17.jpg pcvx-20251231_g18.jpg pcvx-20251231_g19.jpg pcvx-20251231_g2.jpg pcvx-20251231_g20.jpg pcvx-20251231_g21.jpg pcvx-20251231_g22.jpg pcvx-20251231_g23.jpg pcvx-20251231_g24.jpg pcvx-20251231_g25.jpg pcvx-20251231_g26.jpg pcvx-20251231_g27.jpg pcvx-20251231_g28.jpg pcvx-20251231_g29.jpg pcvx-20251231_g3.jpg pcvx-20251231_g30.jpg pcvx-20251231_g31.jpg pcvx-20251231_g32.jpg pcvx-20251231_g33.jpg pcvx-20251231_g34.jpg pcvx-20251231_g35.jpg pcvx-20251231_g36.jpg pcvx-20251231_g37.jpg pcvx-20251231_g38.jpg pcvx-20251231_g39.jpg pcvx-20251231_g4.jpg pcvx-20251231_g40.jpg pcvx-20251231_g41.jpg pcvx-20251231_g42.jpg pcvx-20251231_g5.jpg pcvx-20251231_g6.jpg pcvx-20251231_g7.jpg pcvx-20251231_g8.jpg pcvx-20251231_g9.jpg http://fasb.org/us-gaap/2025 http://xbrl.sec.gov/cyd/2025 http://xbrl.sec.gov/dei/2025 http://xbrl.sec.gov/ecd/2025 true true