X0508 4 2023-10-02 0 0001649094 Vaxcyte, Inc. PCVX 0001258693 PICKERING GRANT C/O VAXCYTE, INC. 825 INDUSTRIAL ROAD, STE. 300 SAN CARLOS CA 94070 1 1 0 0 Chief Executive Officer 1 Common Stock 2023-10-02 4 S 0 641 49.67 D 155880 I By Children's Trust Common Stock 2023-10-02 4 S 0 385 50.76 D 155495 I By Children's Trust Common Stock 2023-10-02 4 S 0 283 51.52 D 155212 I By Children's Trust Common Stock 2023-10-02 4 S 0 646 49.68 D 155875 I By Children's Trust Common Stock 2023-10-02 4 S 0 221 50.48 D 155654 I By Children's Trust Common Stock 2023-10-02 4 S 0 442 51.55 D 155212 I By Children's Trust Common Stock 400914 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on June 26, 2023. The price reported is a weighted-average price. The shares were sold at prices ranging from $49.205 to $50.025. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Shares are held directly by a trust for the benefit of the Reporting Person's daughter. The price reported is a weighted-average price. The shares were sold at prices ranging from $50.31 to $51.245. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $51.505 to $51.565. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $49.195 to $50.025. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Shares are held directly by a trust for the benefit of the Reporting Person's son. The price reported is a weighted-average price. The shares were sold at prices ranging from $50.31 to $50.064. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $51.39 to $51.69. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Grant Pickering, by /s/ Ron A. Metzger, Attorney-in-Fact 2023-10-04