X0306 4 2021-11-19 0 0001649094 Vaxcyte, Inc. PCVX 0001258693 PICKERING GRANT C/O VAXCYTE, INC. 353 HATCH DRIVE FOSTER CITY CA 94404 1 1 0 0 Chief Executive Officer Common Stock 2021-11-19 4 M 0 15000 1.79 A 595254 D Common Stock 2021-11-19 4 S 0 9110 23.09 D 586144 D Common Stock 2021-11-19 4 S 0 5890 24.00 D 580254 D Common Stock 355660 I By Children's Trusts Stock Option (right to buy) 1.79 2021-11-19 4 M 0 15000 0.00 D 2027-05-17 Common Stock 15000 328815 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. The price reported is a weighted-average price. The shares were sold at prices ranging from $22.58 to $23.54. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $23.60 to $24.51. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The shares subject to the option are fully vested and exercisable. /s/ Ron Metzger, Attorney-in-Fact 2021-11-23