X0508 4 2024-05-13 0000097745 THERMO FISHER SCIENTIFIC INC. TMO 0001648929 Williamson Stephen 168 THIRD AVENUE WALTHAM MA 02451 1 Sr. VP and CFO 1 Common Stock 2024-05-13 4 M 0 21925 210.68 A 58406.987 D Common Stock 2024-05-13 4 S 0 21925 591.27 D 36481.987 D Common Stock 2024-05-14 4 G 0 3297 0 D 33184.987 D Common Stock 2024-05-14 4 G 0 12674 0 D 20510.987 D Common Stock 2024-05-14 4 G 0 12674 0 A 12674 I By SLAT Common Stock 8844 I By GRAT Stock Option (Right to Buy) 210.68 2024-05-13 4 M 0 21925 0 D 2025-02-27 Common Stock 21925 0 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 12, 2024. This transaction involves the reporting person's disposition of shares into a Spousal Lifetime Access Trust (SLAT) for the benefit of the reporting person's spouse and/or children. The reporting person's spouse serves as trustee of the SLAT. The reporting person disclaims beneficial ownership of the shares in the SLAT except to the extent the reporting person has a pecuniary interest in such shares. The option vested in four equal installments on February 27, 2019, 2020, 2021, and 2022. /s/ Melodie T. Morin, Attorney-in-Fact for Stephen Williamson 2024-05-15