X0306 4 2015-08-27 0 0001637761 SeaSpine Holdings Corp SPNE 0001646772 Baker Brian D. C/O SEASPINE HOLDINGS CORPORATION, 2302 LA MIRADA DRIVE VISTA CA 92081 0 1 0 0 VP, Global Operations Common Stock 2015-08-27 4 P 0 4600 14.96 A 4600 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.90 to $15.00, inclusive. The reporting person undertakes to provide to SeaSpine, any security holder of SeaSpine, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) to this Form 4. /s/ John Bostjancic, Attorney-in-Fact for Brian D. Baker 2015-08-31