X0306 4 2020-09-16 0 0001604821 Natera, Inc. NTRA 0001646649 Sheena Jonathan C/O NATERA, INC., 201 INDUSTRIAL ROAD SUITE 410 SAN CARLOS CA 94070 1 1 0 0 Chief Technology Officer Common Stock 2020-09-16 4 M 0 10000 1.141 A 265462 D Stock Option (right to buy) 1.141 2020-09-16 4 M 0 10000 0 D 2022-09-20 Common Stock 10000 299950 D No shares were sold by the Reporting Person and the shares received upon exercise of the stock option are subject to a Lock-Up Agreement. The exercise of the option is a permissible exemption under the terms of the Lock-Up Letter Agreement. These reported shares are subject to restrictions in a Lock-Up Letter Agreement that expire on November 10, 2020. The option shares are fully vested and may be exercised at any time. /s/ Tami Chen, attorney-in-fact 2020-09-18