X0306 4 2020-06-30 0 0001604821 Natera, Inc. NTRA 0001646649 Sheena Jonathan C/O NATERA, INC., 201 INDUSTRIAL ROAD SUITE 410 SAN CARLOS CA 94070 1 1 0 0 Chief Technology Officer Common Stock 2020-06-30 4 M 0 28784 9.59 A 277854 D Common Stock 2020-06-30 4 M 0 63331 10.41 A 341185 D Common Stock 2020-06-30 4 S 0 92115 49.4406 D 249070 D Stock Option (right to buy) 9.59 2020-06-30 4 M 0 28784 0 D 2026-04-07 Common Stock 28784 40830 D Stock Option (right to buy) 10.41 2020-06-30 4 M 0 63331 0 D 2027-06-08 Common Stock 63331 39068 D The sales reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 15, 2019. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.00 to $49.97 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option shares vested fully and became exercisable on April 1, 2020. The option shares vest over four years. 25% of the option shares vest and become exercisable on March 21, 2018 and the remaining shares vest in 36 equal monthly installments thereafter. /s/ Tami Chen, attorney-in-fact 2020-07-02