X0306 4 2015-12-30 0 0001604821 Natera, Inc. NTRA 0001646382 Rabinowitz Matthew C/O NATERA, INC. 201 INDUSTRIAL ROAD, SUITE 410 SAN CARLOS CA 94070 1 1 0 0 CEO, President Common Stock 2015-12-30 4 S 0 52118 10.9447 D 2876855 D Common Stock 2015-12-31 4 S 0 59395 10.73 D 2817460 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The reported price in Column 4 is a weighted average. These shares were sold in multiple transactions at prices ranging from $10.4300 to $11.1500 per share, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average. These shares were sold in multiple transactions at prices ranging from $10.2200 to $11.0000 per share, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Meaghan S. Nelson, attorney-in-fact 2016-01-04