X0306 4 2020-09-22 0 0001604821 Natera, Inc. NTRA 0001646382 Rabinowitz Matthew C/O NATERA, INC., 201 INDUSTRIAL ROAD SUITE 410 SAN CARLOS CA 94070 1 1 0 0 Executive Chairman Common Stock 2020-09-22 4 M 0 400 A 572516 D Common Stock 2020-09-23 4 S 0 141 63.3075 D 572375 D Common Stock 540000 I By RMDM Trust Common Stock 613496 I By Matthew Rabinowitz Grantor Retained Annuity Trust Restricted Stock Unit 2020-09-22 4 M 0 400 0 D Common Stock 400 4003 D Represents the partial vesting and settlement of Restricted Stock Units ("RSUs"), starting March 22, 2020. Each RSU represents a contingent right to receive one share of the common stock of the issuer. The sale of shares was effected in order to satisfy tax withholding and remittance obligations in connection with the vesting of RSUs. The Reporting Person is subject to a Lock-Up Letter Agreement. The sale of shares is a permissible exemption under the terms of the Lock-Up Letter Agreement. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.9601 to $63.31 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. These reported shares are subject to restrictions in a Lock-Up Letter Agreement that expire on November 10, 2020. The RMDM Trust is an irrevocable spendthrift trust for the benefit of Mr. Rabinowitz and other discretionary beneficiaries, pursuant to Nevada Revised Statutes Chapter 166. Under the RMDM Trust, Mr. Rabinowitz has no enforceable rights to distributions. The RMDM Trust is a fully discretionary trust and the distribution decisions for the RMDM Trust are vested in a committee. Mr. Rabinowitz disclaims beneficial ownership except to the extent of his pecuniary interest therein. Mr. Rabinowitz is a trustee of the Matthew Rabinowitz Grantor Retained Annuity Trust, and has voting and dispositive power with respect to the reported shares. Mr. Rabinowitz disclaims beneficial ownership except to the extent of his pecuniary interest therein. The RSUs vest over four years. 25% of the RSUs vest on March 22, 2019 and the remaining shares vest in 12 equal quarterly installments thereafter. /s/ Tami Chen, attorney-in-fact 2020-09-23