X0306 4 2022-01-03 0 0001645666 Kezar Life Sciences, Inc. KZR 0001364719 Kauffman Michael C/O KEZAR LIFE SCIENCES, INC. 4000 SHORELINE COURT, SUITE 300 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2022-01-03 4 M 0 5000 5.91 A 68690 D Common Stock 2022-01-03 4 S 0 5000 16.45 D 63690 D Stock Option (Right to Buy) 5.91 2022-01-03 4 M 0 5000 0.00 D 2028-04-15 Common Stock 5000 3896 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.164 to $16.80 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Fully vested and exercisable. /s/ Marc Belsky, Attorney-in-Fact 2022-01-05