<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:own="http://www.sec.gov/edgar/ownership">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001648401</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001645590</own:issuerCik>
      <own:issuerName>Hewlett Packard Enterprise Company</own:issuerName>
      <own:secFileNumber>001-37483</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>1701 East Mossy Oaks Road</com:street1>
        <com:city>Spring</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>77389</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>678-259-9860</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Antonio F. Neri</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>President, CEO, Director</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>J.P. Morgan Securities LLC</own:name>
        <own:address>
          <com:street1>270 Park Avenue, 10th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>750000</own:noOfUnitsSold>
      <own:aggregateMarketValue>41415000</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>1327464779</own:noOfUnitsOutstanding>
      <own:approxSaleDate>09/11/2026</own:approxSaleDate>
      <own:securitiesExchangeName>NYSE</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>05/01/2026</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Transfer</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Antonio F. Neri, who acquired shares from Issuer through compensation between 12/2022 and 12/2024</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>750000</own:amountOfSecuritiesAcquired>
      <own:paymentDate>05/01/2026</own:paymentDate>
      <own:natureOfPayment>Compensation</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:remarks>The shares covered by this filing will be sold by the Antonio Neri Revocable Trust, Antonio F. Neri as Trustee, today or within three months from the date of this filing.</own:remarks>
    <own:noticeSignature>
      <own:noticeDate>09/11/2026</own:noticeDate>
      <own:planAdoptionDates>
        <own:planAdoptionDate>06/04/2026</own:planAdoptionDate>
      </own:planAdoptionDates>
      <own:signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Antonio F. Neri</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
