144 0001333516 XXXXXXXX LIVE 0001645469 MONOPAR THERAPEUTICS INC. 001-39070 1000 Skokie Blvd., Suite 350 Wilmette IL 60091 847-388-0349 KIM TSUCHIMOTO Director Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

8180 906507.60 6712172 08/26/2026 NASDAQ Common 08/26/2026 Exercise of Stock Options Issuer N 8180 08/26/2026 Cash Y The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 08/26/2026 05/27/2026 /s/ Kim Tsuchimoto