X0508 4 2025-03-31 0001645469 Monopar Therapeutics MNPR 0001727334 Robinson Chandler 1000 SKOKIE BLVD SUITE 350 WILMETTE IL 60091 1 1 Chief Executive Officer 0 Common Stock 2025-03-31 4 M 0 4106 A 67197 D Common Stock 2025-03-31 4 F 0 1204 36.41 D 65993 D Common Stock 855589 I See Footnote Restricted Stock Units 2025-03-31 4 M 0 4106 0 D Common Stock 4106 94669 D Represents shares acquired on vesting and settlement of restricted stock units. Represents shares withheld by the issuer to pay for the applicable withholding tax due upon vesting of restricted stock units. As a manager of Tactic Pharma LLC, Dr. Robinson may be deemed to share voting and dispositive power over these 855,589 shares. Dr. Robinson disclaims beneficial ownership of the 855,589 shares held by Tactic Pharma LLC, except to the extent of his pecuniary interest therein. On February 2, 2022, the reporting person was granted 31,905 restricted stock units, vesting 6/48ths (3,988 shares) on June 30, 2022, and 3/48ths (1,994 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2025. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement. On February 1, 2023, the reporting person was granted 33,803 restricted stock units, vesting 6/48ths (4,225 shares) on June 30, 2023, and 3/48ths (2,113 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2026. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement. /s/ Quan Vu, Attorney-in-fact 2025-04-02