X0306 4 2021-11-11 0 0001645460 Cue Biopharma, Inc. CUE 0001739130 Suri Anish C/O CUE BIOPHARMA, INC. 21 ERIE STREET CAMBRIDGE MA 02139 0 1 0 0 President and CSO Common Stock 2021-11-11 4 M 0 20000 6.42 A 114038 D Common Stock 2021-11-11 4 S 0 20000 15.0677 D 94038 D Stock Option (right to buy) 6.42 2021-11-11 4 M 0 20000 0.00 D 2029-03-06 Common Stock 20000 105000 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 15, 2021. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $15.00 to $15.29, inclusive. The reporting person undertakes to provide to Cue Biopharma, Inc., any security holder of Cue Biopharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote (2) to this Form 4. The option vests in eight equal semi-annual installments beginning September 6, 2019. /s/ Anish Suri by Colin Sandercock, attorney-in-fact 2021-11-15