Debt Instrument, Covenant Compliance, Maximum Outstanding Commiments

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Early Termination Fee Payable

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Non-refundable up-front license fee amount.

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- Definition

Operating lease commitments.

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Percentage of tiered royalty rate of net sales.

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Regulatory and commercial milestone payments.

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- Definition

Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due.

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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Percentage points added to the reference rate to compute the variable rate on the debt instrument.

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Period of time between issuance and maturity of debt instrument, in PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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No definition available.

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- Definition

Carrying value of amounts transferred to third parties for security purposes that are expected to be returned or applied towards payment in the future.

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Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
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The carrying value as of the balance sheet date of the current and noncurrent portions of long-term obligations drawn from a line of credit, which is a bank's commitment to make loans up to a specific amount. Examples of items that might be included in the application of this element may consist of letters of credit, standby letters of credit, and revolving credit arrangements, under which borrowings can be made up to a maximum amount as of any point in time conditional on satisfaction of specified terms before, as of and after the date of drawdowns on the line. Includes short-term obligations that would normally be classified as current liabilities but for which (a) postbalance sheet date issuance of a long term obligation to refinance the short term obligation on a long term basis, or (b) the enterprise has entered into a financing agreement that clearly permits the enterprise to refinance the short-term obligation on a long term basis and the following conditions are met (1) the agreement does not expire within 1 year and is not cancelable by the lender except for violation of an objectively determinable provision, (2) no violation exists at the BS date, and (3) the lender has entered into the financing agreement is expected to be financially capable of honoring the agreement.

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- Definition

Maximum borrowing capacity under the credit facility without consideration of any current restrictions on the amount that could be borrowed or the amounts currently outstanding under the facility.

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The fee, expressed as a percentage of the line of credit facility, for available but unused credit capacity under the credit facility.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

Amount of operating lease expense. Excludes sublease income.

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Period in which remaining performance obligation is expected to be recognized as revenue, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Commitments and contingent liabilities - Additional Information (Details) - USD ($)			12 Months Ended
	Nov. 06, 2020	Sep. 10, 2018	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Feb. 22, 2023	Feb. 17, 2023
Loss Contingencies [Line Items]
Lease and rental expense			$ 7,108,000	$ 7,349,000	$ 5,950,000
Pledged bank deposits			2,296,000	2,350,000
Operating lease commitments			2,459,000	2,698,000
Zai License and Collaboration Agreement
Loss Contingencies [Line Items]
Non-refundable up-front license fee, amount		$ 15,000,000
Zai License and Collaboration Agreement \| License
Loss Contingencies [Line Items]
Regulatory and commercial milestone payments					10,000,000
Liability, revenue recognized			$ 4,389,000	$ 6,308,000	$ 3,981,000
Zai License and Collaboration Agreement \| License \| Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date: 2021-01-01
Loss Contingencies [Line Items]
Revenue recognition period			6 years
Minimum \| Zai License and Collaboration Agreement \| License
Loss Contingencies [Line Items]
Percentage of tiered royalties rates on net sales		10.00%
Maximum \| Zai License and Collaboration Agreement
Loss Contingencies [Line Items]
Regulatory and commercial milestone payments		$ 78,000,000
Line of Credit \| Revolving Credit Facility
Loss Contingencies [Line Items]
Contractual term	3 years
Maximum borrowing capacity	$ 150,000,000
Covenant compliance, maximum outstanding commitments	$ 250,000,000
Outstanding balance borrowed under the facility			$ 0
Line of Credit \| Revolving Credit Facility \| Subsequent Event
Loss Contingencies [Line Items]
Outstanding balance borrowed under the facility						$ 0
Early termination fee payable							$ 0
Line of Credit \| Minimum \| Revolving Credit Facility
Loss Contingencies [Line Items]
Fee for unused revolving credit commitments, percentage	0.35%
Line of Credit \| Minimum \| Revolving Credit Facility \| London Interbank Offered Rate (LIBOR)
Loss Contingencies [Line Items]
Basis spread on variable rate	2.75%
Line of Credit \| Maximum \| Revolving Credit Facility
Loss Contingencies [Line Items]
Fee for unused revolving credit commitments, percentage	0.45%
Line of Credit \| Maximum \| Revolving Credit Facility \| London Interbank Offered Rate (LIBOR)
Loss Contingencies [Line Items]
Basis spread on variable rate	3.25%