Cash and Cash equivalents and Short-term investments - Additional Information (Details) - USD ($) $ in Thousands	1 Months Ended
	Nov. 30, 2022	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Cash and Cash Equivalents [Line Items]
Net unrealized loss on securities	$ 911
Cumulative impact to its accumulated deficit		$ 441,170	$ 410,494	$ 476,526	$ 217,790
AOCI, Accumulated Gain (Loss), Debt Securities, Available-for-Sale, Parent
Cash and Cash Equivalents [Line Items]
Cumulative impact to its accumulated deficit		$ 445