Income taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of Income (Loss) before Income Taxes

Income (loss) before income taxes is as follows:

	Year ended December 31,
	2022		2021		2020
Swiss	$	(269,621)	$	(145,591)	$	32,010
Non-Swiss	187,775		93,516		(13,908)
Total income (loss) before income taxes	$	(81,846)	$	(52,075)	$	18,102

Schedule of Components of Income Tax Expense (Benefit)

The provision (benefit) for income taxes from continuing operations is comprised of:

	Year ended December 31,
	2022		2021		2020
Current:
Swiss	$	469	$	281	$	3,105
Non-Swiss	10,219		5,995		(4,811)
Total current	$	10,688	$	6,276	$	(1,706)
Deferred:
Swiss	$	—	—		$	—
Non-Swiss	—		—		—
Total deferred	—		—		—
Total income tax provision	$	10,688	$	6,276	$	(1,706)

Reconciliation of Provision for Income Taxes

A reconciliation of the provision for income taxes compared with the amounts at the Swiss rate was:

	Year ended December 31,
	2022			2021			2020
Income (loss) before income taxes	$	(81,846)		$	(52,075)		$	18,102
Swiss federal statutory rate	8.5		%	8.5		%	8.5		%
Income tax at federal Swiss rate	$	(6,957)		$	(4,426)		$	1,539
Foreign taxes rate differential	25,716			1,601			2,517
Change in valuation allowance	(14,238)			11,643			6,821
Effect of tax law change	5,681			—			(8,694)
Share based compensation	5,318			(4,636)			(1,615)
Research and development credits	(4,898)			(2,216)			(5,243)
Return to provision true-ups	(1,020)			2,416			—
Withholding taxes	548			273			2,366
Other	538			1,621			603
Income tax	$	10,688		$	6,276		$	(1,706)
Effective tax rate	(13.1)		%	(12.1)		%	(9.4)		%

Schedule of Significant Components of Deferred Tax Assets and Liabilities

Significant components of the Company’s deferred tax assets and liabilities are as follows:

	December 31,
	2022		2021
Deferred tax assets:
Unamortized intangible assets	$	153,450	$	138,978
Impact of revenue recognition	$	82,972	$	112,251
Net operating loss carryforwards	$	65,472	$	77,664
Share based compensation	$	30,009	$	25,644
Capitalized research and development	$	16,730	$	—
Research and development credits	$	8,992	$	12,146
Lease liabilities	$	5,846	$	4,836
Interest limitations	$	—	$	7,948
Other temporary differences	$	7,089	$	3,032
Total gross deferred tax assets	$	370,560	$	382,499
Less: valuation allowance	(361,358)		(375,717)
Total deferred tax assets	9,202		6,782
Deferred tax liabilities:
Right of use assets	5,785		4,559
Fixed assets	1,730		2,214
Other liabilities	1,687		9
Total gross deferred tax liabilities	$	9,202	$	6,782
Net deferred taxes assets (liability)	$	—	$	—

Schedule of Reconciliation of Beginning and Ending Amount of Unrecognized Tax Benefits

A reconciliation of the beginning and ending balances of uncertain tax benefits is as follows:

	December 31,
	2022		2021		2020
Balance at beginning of the year	$	154	$	297	$	116
Additions (reductions) for taxes positions related to prior years	(78)		(143)		181
Balance at the end of the year	$	76	$	154	$	297