Share Capital - Additional Information (Details) - USD ($)			1 Months Ended				12 Months Ended
	Dec. 31, 2016	Oct. 07, 2015	Jan. 31, 2016	Jun. 30, 2015	Mar. 31, 2015	Feb. 28, 2015	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Dec. 30, 2016
Share Capital [Line Items]
Voting rights of ordinary shareholder							one
Settlement agreement date							February 2015
Common stock, shares issued	87,066,446						87,066,446	83,778,581
Share-based Compensation Cost						$ 0
Credit facility repayment date							Dec. 31, 2013
Warrants issued to purchase of preferred shares							975,644
Exercise price per share	$ 18.77						$ 18.77
Class of Warrant or Right, Date from which Warrants or Rights Exercisable							Jan. 31, 2016
Increase in number of ordinary shares reserved for grants						2,956,500
Unrecognized compensation cost	$ 20,030,000						$ 20,030,000
Unrecognized compensation cost expected recognition weighted average period							2 years 7 months 28 days
Weighted average grant date fair values options granted							$ 7.37	$ 10.64	$ 5.08
Weighted average grant date fair values options unvested							$ 8.30	$ 8.66	$ 4.26
Weighted average grant date fair values options unvested amount	5,398,204						5,398,204	4,613,423	2,934,974
Weighted average grant date fair values options vested							$ 7.30	$ 3.66	$ 2.89
Weighted average grant date fair values options vested amount							1,572,238	1,235,880	1,166,974
Weighted average grant date fair values options forfeited and cancelled							$ 9.72	$ 5.73	$ 3.59
Aggregate intrinsic values options exercised							$ 7,673,000	$ 3,546,000	$ 3,339,000
Fair value of ordinary shares	$ 7.85						$ 7.85	$ 22.36	$ 7.73
2003 Plan
Share Capital [Line Items]
Option granted vesting period							4 years
Option granted expiration period							10 years
2013 Plan
Share Capital [Line Items]
Option granted vesting period							4 years
Option granted expiration period							10 years
Number of shares available for issuance					13,198,224
Ordinary shares available for grant								0
2015 Plan
Share Capital [Line Items]
Option granted vesting period							4 years
Option granted expiration period							10 years
Number of shares available for issuance	19,730,105						19,730,105			16,251,143
Ordinary shares available for grant	16,136,439						16,136,439
Percentage increase in number of shares available for issuance	4.00%
Condition One
Share Capital [Line Items]
Settlement agreement terms							(i) 18 months after signing of the Agreement, (ii) an IPO or (iii) the earlier of consummation of a merger/acquisition (“M&A”) or achievement of a Cumulative Net Sales milestone of $250,000 (as defined pursuant to the Agreement).
Condition Two
Share Capital [Line Items]
Settlement agreement terms							(i) achievement of the Cumulative Net Sales milestone per above or (ii) consummation of a merger or acquisition transaction
Settlement Agreement
Share Capital [Line Items]
Earlier Payment period after agreement						18 months
Net sales milestone						$ 250,000,000
Common stock, shares issued						1,005,210
Ordinary shares granted						1,005,210
Earlier Period for Option Termination						12 months
Stock redeemed or called during period, shares						2,010,420
Cash obligation					$ 2,000,000		$ 1,945,000		$ 2,000,000
Settlement Agreement | General and Administrative
Share Capital [Line Items]
Settlement expense							$ 5,500,000		$ 1,867,000
Settlement Agreement | Minimum
Share Capital [Line Items]
Percentage of closing price per share					80.00%
Settlement Agreement | Condition One
Share Capital [Line Items]
Settlement expense						$ 1,000,000
Settlement additional payment						1,000,000
Settlement additional amount paid						1,000,000
Settlement Agreement | Condition Two
Share Capital [Line Items]
Settlement additional payment						$ 5,500,000
ESPP
Share Capital [Line Items]
Number of shares available for issuance	2,537,526						2,537,526			1,667,785
Ordinary shares available for grant	2,445,138						2,445,138
Increase in shares authorized for issuance available for grants	830,000						830,000
Percentage of increase in shares outstanding							1.00%
Ordinary Shares
Share Capital [Line Items]
Conversion of preferred shares to ordinary shares								62,744,517
Issuance of shares in connection with employee stock purchase plan(in shares)							92,388
Ordinary Shares | IPO
Share Capital [Line Items]
Sale of ordinary shares		7,876,195
Proceeds from issuance of ordinary shares		$ 157,534,000
Ordinary Shares | ESPP
Share Capital [Line Items]
Issuance of shares in connection with employee stock purchase plan(in shares)							92,388
Warrant
Share Capital [Line Items]
Conversion of preferred shares to ordinary shares			315,155				864,341	570,344
Series J Convertible Preferred shares
Share Capital [Line Items]
Shares issued				4,068,500
Shares issued, price per share				$ 23.33
Proceeds from issuance of preferred shares, net				$ 94,599,000
Share issuance expenses				$ 319,000
Liquidation preference per share				$ 23.33