144 0001644975 XXXXXXXX LIVE 0001933414 Mineralys Therapeutics, Inc. 001-41614 150 N. RADNOR CHESTER RD. SUITE F200 RADNOR PA 19087 (888) 378-6240 Congleton Jon Officer Common Stock Merrill Lynch

225 Liberty Street Floor 37 New York NY 10281

15730 421979.55 82399478 04/13/2026 NASDAQ Common Stock 04/10/2026 Vesting of restricted share unit award Mineralys Therapeutics, Inc. N 15730 04/10/2026 Granted as part of issuer equity compensation plan N Jon Congleton

150 N. RADNOR CHESTER RD. SUITE F200 RADNOR PA 19087

Common Stock 01/12/2026 16236 529639.51 Jon Congleton

150 N. RADNOR CHESTER RD SUITE F200 RADNOR PA 19087

Common Stock 03/31/2026 75000 1970520.69 04/13/2026 01/28/2025 Jon Congleton