X0306 4 2015-12-11 0 0001626199 Nivalis Therapeutics, Inc. NVLS 0001644975 Congleton Jon C/O NIVALIS THERAPEUTICS, INC. 3122 STERLING CIRCLE, SUITE 200 BOULDER CO 80301 1 1 0 0 President and CEO Common Stock 2015-12-11 4 P 0 5000 8.10 A 5000 D The price recorded in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.04 to $8.18, inclusive. The reporting person undertakes to provide Nivalis Therapeutics, Inc., any security holder of Nivalis Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this Form 4. /s/ R. Michael Carruthers, Attorney-in-Fact 2015-12-14