X0306 4 2019-02-19 0 0001343304 AVEDRO INC AVDR 0001644557 Burns Thomas William C/O AVEDRO, INC. 201 JONES ROAD WALTHAM MA 02451 1 0 0 0 Stock Option (right to buy) 12.73 2019-02-19 4 A 0 8314 0.00 A 2029-01-08 Common Stock 8314 8314 D One hundred percent (100%) of the shares subject to the option shall vest on the earlier of (x) June 1, 2020 and (y) the first anniversary of the first annual meeting of the Issuer's stockholders following the Issuer's initial public offering, subject to the Reporting Person continuing to provide service through such date. /s/ Paul S. Bavier, Attorney-in-Fact 2019-02-19