144 0001644467 XXXXXXXX LIVE 0001710072 EDGEWISE THERAPEUTICS, INC. 001-40236 1715 38th Street Boulder CO 80301 (720) 262-7002 ROBERT MICHAEL CARRUTHERS Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

116665 3039811.57 105868434 12/26/2025 NASDAQ Common 12/26/2025 Exercise of options under a registered plan Issuer N 116665 12/26/2025 Not Applicable N ROBERT MICHAEL CARRUTHERS

1715 38th Street Boulder CO 80301

Common 11/17/2025 70000 1566586.00 Sales that were executed on December 26, 2025 are being reported on this Form 144 filed on December 29, 2025 given December 26, 2025 were treated as federal holidays for EDGAR filing purposes. 12/29/2025 Robert Michael Carruthers