144 0001644162 XXXXXXXX LIVE 0000873303 Sarepta Therapeutics, Inc. 001-14895 215 FIRST STREET SUITE 415 CAMBRIDGE MA 02142 617-274-4000 Nicaise Claude Director Common Morgan Stanley Smith Barney LLC Executive Services

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2491 248225.83 97000000 03/12/2025 NASDAQ COMMON 03/12/2025 STOCK OPTION EXERCISE ISSUER N 2491 03/12/2025 COMPENSATION Y 03/12/2025 /s/ Claude Nicaise