X0306 4 2020-10-05 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001643921 Bhatia Sangeeta N. C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 Common Stock 2020-10-05 4 M 0 8729 126.68 A 14424 D Common Stock 2020-10-05 4 S 0 291 262.66 D 14133 D Common Stock 2020-10-05 4 S 0 594 263.54 D 13539 D Common Stock 2020-10-05 4 S 0 892 264.60 D 12647 D Common Stock 2020-10-05 4 S 0 1787 265.82 D 10860 D Common Stock 2020-10-05 4 S 0 2070 266.66 D 8790 D Common Stock 2020-10-05 4 S 0 2670 267.92 D 6120 D Common Stock 2020-10-05 4 S 0 2212 268.61 D 3908 D Stock Option (Right to Buy) 126.68 2020-10-05 4 M 0 8729 0.00 D 2025-06-03 Common Stock 8729 0 D Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $262.66 (range $262.10 to $263.06). Dr. Bhatia undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $263.54 (range $263.12 to $264.01). Open market sales reported on this line occurred at a weighted average price of $264.60 (range $264.18 to $264.92). Open market sales reported on this line occurred at a weighted average price of $265.82 (range $265.25 to $266.19). Open market sales reported on this line occurred at a weighted average price of $266.66 (range $266.27 to $267.16). Open market sales reported on this line occurred at a weighted average price of $267.92 (range $267.39 to $268.35). Open market sales reported on this line occurred at a weighted average price of $268.61 (range $268.39 to $269.00). Fully vested. /s/ Sabrina Yohai, Attorney-in-Fact 2020-10-07