X0306 4 2020-06-01 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001643921 Bhatia Sangeeta N. C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 Common Stock 2020-06-01 4 A 0 1398 0.00 A 6647 D Common Stock 2020-06-02 4 S 0 50 279.52 D 6597 D Common Stock 2020-06-02 4 S 0 200 281.20 D 6397 D Common Stock 2020-06-02 4 S 0 313 282.86 D 6084 D Common Stock 2020-06-02 4 S 0 289 283.84 D 5795 D Common Stock 2020-06-02 4 S 0 50 284.62 D 5745 D Common Stock 2020-06-02 4 S 0 50 285.73 D 5695 D Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date. Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $281.20 (range $281.01 to $281.66). Dr. Bhatia undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $282.86 (range $282.36 to $283.31). Open market sales reported on this line occurred at a weighted average price of $283.84 (range $283.47 to $284.23). /s/ Sabrina Yohai, Attorney-in-Fact 2020-06-03