X0306 4 2019-06-01 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001643921 Bhatia Sangeeta N. C/O VERTEX PHARMACEUTICALS INCORPORATED BOSTON MA 02210 1 0 0 0 Common Stock 2019-06-01 4 A 0 2381 0.00 A 7260 D Common Stock 2019-06-03 4 S 0 400 166.52 D 6860 D Common Stock 2019-06-03 4 S 0 320 167.78 D 6540 D Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date. Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $166.52 (range $165.91 to $166.86). Dr. Bhatia undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $167.78 (range $167.00 to $168.42). /s/ Omar White, Attorney-in-Fact 2019-06-04