X0306 4 2022-08-08 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001643921 Bhatia Sangeeta N. C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 Common Stock 2022-08-08 4 S 0 45 290.18 D 5237 D Common Stock 2022-08-08 4 S 0 164 291.76 D 5073 D Common Stock 2022-08-08 4 S 0 204 293.15 D 4869 D Common Stock 2022-08-08 4 S 0 161 294.24 D 4708 D Common Stock 2022-08-08 4 S 0 47 295.53 D 4661 D Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1. Dr. Bhatia undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $290.18 (range $290.05 to $290.20). Open market sales reported on this line occurred at a weighted average price of $291.76 (range $291.59 to $291.91). Open market sales reported on this line occurred at a weighted average price of $293.15 (range $292.71 to $293.61). Open market sales reported on this line occurred at a weighted average price of $294.24 (range $293.85 to $294.49). /s/ Joy Liu, Attorney-in-Fact 2022-08-10