X0306 4 2022-07-29 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001643921 Bhatia Sangeeta N. C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 Common Stock 2022-07-29 4 S 0 99 276.65 D 5804 D Common Stock 2022-07-29 4 S 0 200 277.95 D 5604 D Common Stock 2022-07-29 4 S 0 160 279.28 D 5444 D Common Stock 2022-07-29 4 S 0 99 280.22 D 5345 D Common Stock 2022-07-29 4 S 0 58 281.03 D 5287 D Common Stock 2022-07-29 4 S 0 5 282.34 D 5282 D Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1. Dr. Bhatia undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $276.65 (range $276.21 to $276.83). Open market sales reported on this line occurred at a weighted average price of $277.95 (range $277.63 to $278.35). Open market sales reported on this line occurred at a weighted average price of $279.28 (range $278.86 to $279.83). Open market sales reported on this line occurred at a weighted average price of $280.22 (range $279.88 to $280.78). Open market sales reported on this line occurred at a weighted average price of $281.03 (range $280.93 to $281.08). /s/ Joy Liu, Attorney-in-Fact 2022-08-02