X0306 4 2022-05-02 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001643921 Bhatia Sangeeta N. C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 Common Stock 2022-05-02 4 S 0 40 255.40 D 6600 D Common Stock 2022-05-02 4 S 0 280 257.51 D 6320 D Common Stock 2022-05-02 4 S 0 120 258.90 D 6200 D Common Stock 2022-05-02 4 S 0 120 259.75 D 6080 D Common Stock 2022-05-02 4 S 0 80 260.82 D 6000 D Common Stock 2022-05-02 4 S 0 91 261.91 D 5909 D Common Stock 2022-05-02 4 S 0 6 264.37 D 5903 D Transaction made pursuant to Dr. Bhatia's company approved trading plan under Rule 10b5-1. Dr. Bhatia undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $257.51 (range $257.15 to $258.09). Open market sales reported on this line occurred at a weighted average price of $258.90 (range $258.32 to $259.19). Open market sales reported on this line occurred at a weighted average price of $259.75 (range $259.35 to $260.14). Open market sales reported on this line occurred at a weighted average price of $260.82 (range $260.49 to $261.15). Open market sales reported on this line occurred at a weighted average price of $261.91 (range $261.69 to $262.09). /s/ Sabrina Yohai, Attorney-in-Fact 2022-05-04