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    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001643154</cik>
        <entityName>iANTHUS CAPITAL HOLDINGS, INC.</entityName>
        <issuerAddress>
            <street1>SUITE 2740, 22 ADELAIDE STREET</street1>
            <city>TORONTO</city>
            <stateOrCountry>A6</stateOrCountry>
            <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
            <zipCode>M5H 4E3</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>416.591-1525</issuerPhoneNumber>
        <jurisdictionOfInc>BRITISH COLUMBIA, CANADA</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>GENARCA HOLDINGS LTD</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
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    </primaryIssuer>

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            <relatedPersonName>
                <firstName>HADLEY</firstName>
                <lastName>FORD</lastName>
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            <relatedPersonAddress>
                <street1>505 FIFTH AVENUE, 23rd FLOOR</street1>
                <city>NEW YORK</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10017</zipCode>
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                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
                <relationship>Promoter</relationship>
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            <relationshipClarification>CEO</relationshipClarification>
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                <firstName>RANDY</firstName>
                <lastName>MASLOW</lastName>
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                <city>NEW YORK</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10017</zipCode>
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                <relationship>Director</relationship>
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            <relationshipClarification>President</relationshipClarification>
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                <firstName>ELIZABETH</firstName>
                <lastName>STAVOLA</lastName>
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                <street1>505 FIFTH AVENUE, 23rd FLOOR</street1>
                <city>NEW YORK</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10017</zipCode>
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            <relatedPersonRelationshipList>
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                <relationship>Director</relationship>
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            <relationshipClarification>CSO</relationshipClarification>
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            <relatedPersonName>
                <firstName>JULIUS</firstName>
                <lastName>KALCEVICH</lastName>
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                <street1>SUITE 2740, 22 ADELAIDE STREET</street1>
                <city>TORONTO</city>
                <stateOrCountry>A6</stateOrCountry>
                <stateOrCountryDescription>ONTARIO, CANADA</stateOrCountryDescription>
                <zipCode>M5H 4E3</zipCode>
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                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
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            <relationshipClarification>CFO</relationshipClarification>
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            <relatedPersonName>
                <firstName>ROBERT</firstName>
                <middleName>M</middleName>
                <lastName>WHELAN JR.</lastName>
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                <city>NEW YORK</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10017</zipCode>
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                <firstName>PAT</firstName>
                <lastName>TIERNAN</lastName>
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                <zipCode>10017</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification>COO</relationshipClarification>
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                <firstName>MICHAEL</firstName>
                <middleName>P</middleName>
                <lastName>MULDOWNEY</lastName>
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                <street1>505 FIFTH AVENUE, 23rd FLOOR</street1>
                <city>NEW YORK</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10017</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>DIANE</firstName>
                <middleName>M</middleName>
                <lastName>ELLIS</lastName>
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                <street1>505 FIFTH AVENUE, 23rd FLOOR</street1>
                <city>NEW YORK</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10017</zipCode>
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                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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            <relatedPersonName>
                <firstName>JOY</firstName>
                <lastName>CHEN</lastName>
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                <street1>505 FIFTH AVENUE, 23rd FLOOR</street1>
                <city>NEW YORK</city>
                <stateOrCountry>NY</stateOrCountry>
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                <zipCode>10017</zipCode>
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                <relationship>Director</relationship>
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                <firstName>RICHARD</firstName>
                <lastName>BOXER</lastName>
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                <street1>505 FIFTH AVENUE, 23rd FLOOR</street1>
                <city>NEW YORK</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10017</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification>CMO</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>JOHN</firstName>
                <lastName>HENDERSON</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>505 FIFTH AVENUE, 23rd FLOOR</street1>
                <city>NEW YORK</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10017</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Senior VP, Eastern Operations</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>ETHAN</firstName>
                <lastName>ANDERSON</lastName>
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            <relatedPersonAddress>
                <street1>505 FIFTH AVENUE, 23rd FLOOR</street1>
                <city>NEW YORK</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10017</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Senior VP of Marketing</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>TODD</firstName>
                <lastName>KARNIG</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>505 FIFTH AVENUE, 23rd FLOOR</street1>
                <city>NEW YORK</city>
                <stateOrCountry>NY</stateOrCountry>
                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10017</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification>Senior VP, Western Operations</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>RAY</firstName>
                <lastName>CHEVALIER</lastName>
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                <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                <zipCode>10017</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification>VP Infrastructure</relationshipClarification>
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    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Other</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001183740-19-000045</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2019-03-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Unsecured 8% convertible debenture due March 15, 2023; principal convertible at $5.92/common share, and up to 50% of interest convertible at market price. Plus warrants.</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>31993771</totalOfferingAmount>
            <totalAmountSold>26593333</totalAmountSold>
            <totalRemaining>5400438</totalRemaining>
            <clarificationOfResponse>Total Offering Amount: (a) $26M Debentures; (b) $3,993,777* interest plus (c) $1,999,994 warrants (311041x$6.43). There is no assurance the warrants, expiring 15-Mar-2022, will be exercised. *Interest payable subject to decrease if principal is converted.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>3</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
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                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
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            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
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            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>iANTHUS CAPITAL HOLDINGS, INC.</issuerName>
                <signatureName>/s/ Julius Kalcevich</signatureName>
                <nameOfSigner>JULIUS KALCEVICH</nameOfSigner>
                <signatureTitle>CHIEF FINANCIAL OFFICER</signatureTitle>
                <signatureDate>2020-03-17</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
