X0306 4 2022-03-10 0 0001642545 Shockwave Medical, Inc. SWAV 0001768408 Papiernik Antoine C/O SHOCKWAVE MEDICAL, INC. 5403 BETSY ROSS DRIVE SANTA CLARA CA 95054 1 0 0 0 Common Stock 2022-03-10 4 S 0 5494 161.61 D 116757 I By Sofinnova Capital VII FCPR Common Stock 2022-03-10 4 S 0 17907 162.51 D 98850 I By Sofinnova Capital VII FCPR Common Stock 2022-03-10 4 S 0 19424 163.53 D 79426 I By Sofinnova Capital VII FCPR Common Stock 2022-03-10 4 S 0 12729 164.43 D 66697 I By Sofinnova Capital VII FCPR Common Stock 2022-03-10 4 S 0 4446 165.40 D 62251 I By Sofinnova Capital VII FCPR Common Stock 3551 D The price reported in Column 4 is a weighted average price. The reported securities were sold in multiple transactions at prices ranging from $161.00 to $161.96. The reporting person undertakes to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. Represents shares directly held by Sofinnova Capital VII FCPR. The reporting person is one of the managing partners of Sofinnova Partners SAS, a French corporation and the management company of Sofinnova Capital VII FCPR. The reporting person disclaims beneficial ownership of the reported securities except to the extent of his pecuniary interest. The price reported in Column 4 is a weighted average price. The reported securities were sold in multiple transactions at prices ranging from $162.00 to $162.99. The reporting person undertakes to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. The price reported in Column 4 is a weighted average price. The reported securities were sold in multiple transactions at prices ranging from $163.00 to $163.99. The reporting person undertakes to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. The price reported in Column 4 is a weighted average price. The reported securities were sold in multiple transactions at prices ranging from $164.03 to $164.94. The reporting person undertakes to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. The price reported in Column 4 is a weighted average price. The reported securities were sold in multiple transactions at prices ranging from $165.25 to $165.40. The reporting person undertakes to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. /s/ Wade Estey, as attorney-in-fact for Antoine Papiernik 2022-03-11